Abstract：
UNASSIGNED: There is a lack of randomized clinical trial (RCT) data to guide many routine decisions in the care of children hospitalized for common conditions. A first step in addressing the shortage of RCTs for this population is to identify the most pressing RCT questions for children hospitalized with common conditions.
UNASSIGNED: To identify the most important and feasible RCT questions for children hospitalized with common conditions.
UNASSIGNED: For this consensus statement, a 3-stage modified Delphi process was used in a virtual conference series spanning January 1 to September 29, 2022. Forty-six individuals from 30 different institutions participated in the process. Stage 1 involved construction of RCT questions for the 10 most common pediatric conditions leading to hospitalization. Participants used condition-specific guidelines and reviews from a structured literature search to inform their development of RCT questions. During stage 2, RCT questions were refined and scored according to importance. Stage 3 incorporated public comment and feasibility with the prioritization of RCT questions.
UNASSIGNED: The main outcome was RCT questions framed in a PICO (population, intervention, control, and outcome) format and ranked according to importance and feasibility; score choices ranged from 1 to 9, with higher scores indicating greater importance and feasibility.
UNASSIGNED: Forty-six individuals (38 who shared demographic data; 24 women [63%]) from 30 different institutions participated in our modified Delphi process. Participants included children\'s hospital (n = 14) and community hospital (n = 13) pediatricians, parents of hospitalized children (n = 4), other clinicians (n = 2), biostatisticians (n = 2), and other researchers (n = 11). The process yielded 62 unique RCT questions, most of which are pragmatic, comparing interventions in widespread use for which definitive effectiveness data are lacking. Overall scores for importance and feasibility of the RCT questions ranged from 1 to 9, with a median of 5 (IQR, 4-7). Six of the top 10 selected questions focused on determining optimal antibiotic regimens for 3 common infections (pneumonia, urinary tract infection, and cellulitis).
UNASSIGNED: This consensus statementhas identified the most important and feasible RCT questions for children hospitalized with common conditions. This list of RCT questions can guide investigators and funders in conducting impactful trials to improve care and outcomes for hospitalized children.
UNASSIGNED: To identify the most important and feasible RCT questions for children hospitalized with common conditions.
UNASSIGNED: For this consensus statement, a 3-stage modified Delphi process was used in a virtual conference series spanning January 1 to September 29, 2022. Forty-six individuals from 30 different institutions participated in the process. Stage 1 involved construction of RCT questions for the 10 most common pediatric conditions leading to hospitalization. Participants used condition-specific guidelines and reviews from a structured literature search to inform their development of RCT questions. During stage 2, RCT questions were refined and scored according to importance. Stage 3 incorporated public comment and feasibility with the prioritization of RCT questions.
UNASSIGNED: The main outcome was RCT questions framed in a PICO (population, intervention, control, and outcome) format and ranked according to importance and feasibility; score choices ranged from 1 to 9, with higher scores indicating greater importance and feasibility.
UNASSIGNED: Forty-six individuals (38 who shared demographic data; 24 women [63%]) from 30 different institutions participated in our modified Delphi process. Participants included children\'s hospital (n = 14) and community hospital (n = 13) pediatricians, parents of hospitalized children (n = 4), other clinicians (n = 2), biostatisticians (n = 2), and other researchers (n = 11). The process yielded 62 unique RCT questions, most of which are pragmatic, comparing interventions in widespread use for which definitive effectiveness data are lacking. Overall scores for importance and feasibility of the RCT questions ranged from 1 to 9, with a median of 5 (IQR, 4-7). Six of the top 10 selected questions focused on determining optimal antibiotic regimens for 3 common infections (pneumonia, urinary tract infection, and cellulitis).
UNASSIGNED: This consensus statementhas identified the most important and feasible RCT questions for children hospitalized with common conditions. This list of RCT questions can guide investigators and funders in conducting impactful trials to improve care and outcomes for hospitalized children.
摘要：
■缺乏随机临床试验（RCT）数据来指导因常见病住院的儿童护理中的许多常规决策。解决该人群RCT短缺的第一步是为患有常见病的儿童确定最紧迫的RCT问题。
■为患有常见病的住院儿童确定最重要和可行的RCT问题。
■对于本共识声明，在2022年1月1日至9月29日的虚拟会议系列中使用了3阶段改进的Delphi流程.来自30个不同机构的46人参与了这一进程。第一阶段涉及针对导致住院的10种最常见儿科疾病的RCT问题的构建。参与者使用针对特定条件的指南和结构化文献检索的评论来告知他们对RCT问题的发展。在第2阶段，根据重要性对RCT问题进行了细化和评分。第3阶段将公众意见和可行性与RCT问题的优先次序结合起来。
■主要结果是在PICO中提出的RCT问题(人口，干预，control,和结果）格式并根据重要性和可行性进行排名；得分选择范围从1到9，得分越高表明重要性和可行性越大。
■来自30个不同机构的46人（38人共享人口统计数据；24名女性[63%]）参加了我们修改的德尔菲程序。参与者包括儿童医院（n=14）和社区医院（n=13）儿科医生，住院儿童的父母（n=4），其他临床医生（n=2），生物统计学家(n=2)，和其他研究人员（n=11）。该过程产生了62个独特的RCT问题，其中大多数是务实的，比较缺乏确切有效性数据的广泛使用的干预措施。RCT问题的重要性和可行性的总分从1到9不等，中位数为5(IQR，4-7).选择的前10个问题中有6个集中在确定3种常见感染的最佳抗生素方案（肺炎，尿路感染,和蜂窝织炎）。
■这一共识状态确定了住院儿童常见疾病的最重要和可行的RCT问题。此RCT问题列表可以指导研究人员和资助者进行有影响力的试验，以改善住院儿童的护理和结果。
■为患有常见病的住院儿童确定最重要和可行的RCT问题。
■对于本共识声明，在2022年1月1日至9月29日的虚拟会议系列中使用了3阶段改进的Delphi流程.来自30个不同机构的46人参与了这一进程。第一阶段涉及针对导致住院的10种最常见儿科疾病的RCT问题的构建。参与者使用针对特定条件的指南和结构化文献检索的评论来告知他们对RCT问题的发展。在第2阶段，根据重要性对RCT问题进行了细化和评分。第3阶段将公众意见和可行性与RCT问题的优先次序结合起来。
■主要结果是在PICO中提出的RCT问题(人口，干预，control,和结果）格式并根据重要性和可行性进行排名；得分选择范围从1到9，得分越高表明重要性和可行性越大。
■来自30个不同机构的46人（38人共享人口统计数据；24名女性[63%]）参加了我们修改的德尔菲程序。参与者包括儿童医院（n=14）和社区医院（n=13）儿科医生，住院儿童的父母（n=4），其他临床医生（n=2），生物统计学家(n=2)，和其他研究人员（n=11）。该过程产生了62个独特的RCT问题，其中大多数是务实的，比较缺乏确切有效性数据的广泛使用的干预措施。RCT问题的重要性和可行性的总分从1到9不等，中位数为5(IQR，4-7).选择的前10个问题中有6个集中在确定3种常见感染的最佳抗生素方案（肺炎，尿路感染,和蜂窝织炎）。
■这一共识状态确定了住院儿童常见疾病的最重要和可行的RCT问题。此RCT问题列表可以指导研究人员和资助者进行有影响力的试验，以改善住院儿童的护理和结果。
