PDF(Pubmed)
Abstract：
Kidney transplant recipients (KTRs) have been identified as a population at increased risk for severe SARS-CoV-2 infection outcomes. This study focused on understanding the immune response of KTRs post-vaccination, specifically examining both serological and cellular responses to the SARS-CoV-2 vaccine. Thirteen individuals, including seven KTRs and six healthy donors, were evaluated for antibody levels and T cell responses post-vaccination. The study revealed that KTRs had significantly lower serological responses, including reduced anti-receptor binding domain (RBD) binding antibodies and neutralizing antibodies against the Wuhan, Delta, and Omicron BA.2 strains. Additionally, KTRs demonstrated weaker CD8 T cell cytotoxic responses and lower Th1 cytokine secretion, particularly IFN-γ, after stimulation with variant spike peptide pools. These findings highlight the compromised immunity in KTRs post-vaccination and underscore the need for tailored strategies to bolster immune responses in this vulnerable group. Further investigations are warranted into the mechanisms underlying reduced vaccine efficacy in KTRs and potential therapeutic interventions.
OBJECTIVE: Some studies have revealed that KTRs had lower serological response against SARS-CoV-2 than healthy people. Nevertheless, limited studies investigate the cellular response against SARS-CoV-2 in KTRs receiving SARS-CoV-2 vaccines. Here, we found that KTRs have lower serological and cellular responses. Moreover, we found that KTRs had a significantly lower IFN-γ secretion than healthy individuals when their PBMCs were stimulated with SARS-CoV-2 spike peptide pools. Thus, our findings suggested that additional strategies are needed to enhance KTR immunity triggered by the vaccine.
OBJECTIVE: Some studies have revealed that KTRs had lower serological response against SARS-CoV-2 than healthy people. Nevertheless, limited studies investigate the cellular response against SARS-CoV-2 in KTRs receiving SARS-CoV-2 vaccines. Here, we found that KTRs have lower serological and cellular responses. Moreover, we found that KTRs had a significantly lower IFN-γ secretion than healthy individuals when their PBMCs were stimulated with SARS-CoV-2 spike peptide pools. Thus, our findings suggested that additional strategies are needed to enhance KTR immunity triggered by the vaccine.
摘要：
肾移植受者（KTR）已被确定为严重SARS-CoV-2感染结果风险增加的人群。这项研究的重点是了解KTRs疫苗接种后的免疫反应，特异性检查SARS-CoV-2疫苗的血清学和细胞反应。13个人，包括七个KTR和六个健康捐赠者，评估疫苗接种后的抗体水平和T细胞反应。研究表明，KTRs的血清学反应明显较低，包括减少抗受体结合域（RBD）结合抗体和抗武汉中和抗体，Delta,和OmicronBA.2菌株。此外,KTRs表现出较弱的CD8T细胞毒性反应和较低的Th1细胞因子分泌，特别是IFN-γ，用变体刺突肽池刺激后。这些发现突出了KTRs疫苗接种后的免疫力受损，并强调了需要量身定制的策略来支持这一弱势群体的免疫反应。有必要进一步研究KTRs中疫苗功效降低的潜在机制和潜在的治疗干预措施。
目的：一些研究表明，KTRs对SARS-CoV-2的血清学反应低于健康人。然而，有限的研究调查了接受SARS-CoV-2疫苗的KTRs对SARS-CoV-2的细胞反应。这里,我们发现KTRs具有较低的血清学和细胞反应。此外，我们发现,当他们的PBMC受到SARS-CoV-2刺突肽池刺激时,KTRs的IFN-γ分泌显著低于健康个体.因此，我们的研究结果表明,需要额外的策略来增强由疫苗引发的KTR免疫.
目的：一些研究表明，KTRs对SARS-CoV-2的血清学反应低于健康人。然而，有限的研究调查了接受SARS-CoV-2疫苗的KTRs对SARS-CoV-2的细胞反应。这里,我们发现KTRs具有较低的血清学和细胞反应。此外，我们发现,当他们的PBMC受到SARS-CoV-2刺突肽池刺激时,KTRs的IFN-γ分泌显著低于健康个体.因此，我们的研究结果表明,需要额外的策略来增强由疫苗引发的KTR免疫.
