Abstract：
Obesity has become a major global problem that significantly confers an increased risk of developing life-threatening complications, including type 2 diabetes mellitus, fatty liver disease and cardiovascular diseases. Protein arginine methyltransferases (PRMTs) are enzymes that catalyse the methylation of target proteins. They are ubiquitous in eukaryotes and regulate transcription, splicing, cell metabolism and RNA biology. As a key, epigenetically modified enzyme, protein arginine methyltransferase 1 (PRMT1) is involved in obesity-related metabolic processes, such as lipid metabolism, the insulin signalling pathway, energy balance and inflammation, and plays an important role in the pathology of obesity-related metabolic disorders. This review summarizes recent research on the role of PRMT1 in obesity-related metabolic disorders. The primary objective was to comprehensively elucidate the functional role and regulatory mechanisms of PRMT1. Moreover, this study attempts to review the pathogenesis of PRMT1-mediated obesity-related metabolic disorders, thereby offering pivotal information for further studies and clinical treatment.
摘要：
肥胖已经成为一个主要的全球性问题，它显著增加了发生危及生命的并发症的风险。包括2型糖尿病,脂肪肝和心血管疾病。蛋白质精氨酸甲基转移酶(PRMT)是催化靶蛋白甲基化的酶。它们在真核生物中普遍存在并调节转录，拼接,细胞代谢和RNA生物学。作为一把钥匙,表观遗传修饰酶，蛋白质精氨酸甲基转移酶1（PRMT1）参与肥胖相关的代谢过程，比如脂质代谢，胰岛素信号通路，能量平衡和炎症，并在肥胖相关代谢紊乱的病理学中起重要作用。本文就PRMT1在肥胖相关代谢紊乱中的作用研究进展作一综述。主要目的是全面阐明PRMT1的功能作用和调节机制。此外，本研究试图综述PRMT1介导的肥胖相关代谢紊乱的发病机制,从而为进一步的研究和临床治疗提供了关键的信息。
