PDF(Pubmed)
Abstract：
Consumption of dietary fiber has been linked to several health benefits. Among these, dietary fiber breakdown through the process of anaerobic fermentation by the colonic microbiota leads to the production of beneficial metabolites, mainly short-chain fatty acids (acetate, propionate, and butyrate), which have been implicated in reduced calorie intake. Nevertheless, the link between gut microbiota and obesity remains unclear. We investigated the effects of dietary fibers on food intake and body weight gain in two independent but similarly designed studies in rats. In the first study, the inclusion of 10% w/w pectin, fructooligosaccharides or beta-glucan (n = 10/group) in the diets each significantly reduced body weight gain (\'responders\') compared to the cellulose control whereas, in a closely matched, but not fully identical study (n = 8/group), no effect of dietary fiber on body weight (\'non-responders\') was observed. The aim of this work was to explore the basis of this differential response between the two similarly designed and comparable studies, with a focus on the potential role of the gut microbiota in the control of food intake and body weight.
摘要：
膳食纤维的消费与几种健康益处有关。其中,膳食纤维通过结肠微生物群的厌氧发酵过程分解，导致有益代谢产物的产生，主要是短链脂肪酸(乙酸酯，丙酸盐,和丁酸盐)，这与卡路里摄入量的减少有关。然而，肠道菌群与肥胖之间的联系尚不清楚.我们在两项独立但设计相似的大鼠研究中，研究了膳食纤维对食物摄入量和体重增加的影响。在第一项研究中，包含10%w/w果胶，与纤维素对照相比，饮食中的低聚果糖或β-葡聚糖（n=10/组）均显着降低了体重增加（“响应者”），而在一个紧密匹配的，但不完全相同的研究（n=8/组），未观察到膳食纤维对体重的影响(“无反应者”)。这项工作的目的是探索两个类似设计和可比研究之间的这种差异反应的基础，重点关注肠道菌群在控制食物摄入和体重方面的潜在作用。
