PDF(Pubmed)
Abstract：
UNASSIGNED: Aging is a natural process and is often associated with an increased incidence of cognitive impairment. Physical exercise, diet, and leisure activities (music, dance, and art) are some of the lifestyle factors that contribute to healthy aging. The present study aims to explore the differences in cognitive functioning between aging individuals involved in musical activity throughout their lifetime and the ones who were not.
UNASSIGNED: Fifty-one healthy elderly individuals (50-80 years of age) residing in an urban locality were selected for the study from the Tata Longitudinal Study of Aging cohort. Participants were divided into two groups: Active musicians trained in Carnatic music for more than five years (n = 18) and age-matched non-musicians (n = 33). Addenbrooke cognitive examination-III, Hindi mental status examination, and trail-making test-B (TMT-B) were used to assess cognitive functioning. A Generalized Linear Regression Model was performed including covariates such as gender, age, and years of education. We also looked at the available brain magnetic resonance imaging data of a subset of our study population to inspect the volumetric differences between musicians and non-musicians.
UNASSIGNED: Our results showed that musicians had significantly better visuospatial abilities as compared to non-musicians (P = 0.043). Musicians (130.89 ± 45.16 s) also took less time to complete the TMT-B task than non-musicians (148.73 ± 39.65 s), although it was not a statistically significant difference (P =0.150). In addition, brain imaging data suggested that musicians had increased gray matter volumes in the right precuneus, right post-central gyrus, right medial and superior frontal gyrus, right orbital gyrus, left middle temporal gyrus, left cuneus, left fusiform gyrus, and bilateral cingulate gyrus.
UNASSIGNED: Our findings are indicative of music being an important attribute in improving cognitive reserve and predicting cognitive resilience. These findings pave the way to explore the utility of non-pharmacological interventions, such as Music Therapy (especially Carnatic music in the Indian context), as a potential factor for improving cognitive reserve in elderly individuals.
UNASSIGNED: Fifty-one healthy elderly individuals (50-80 years of age) residing in an urban locality were selected for the study from the Tata Longitudinal Study of Aging cohort. Participants were divided into two groups: Active musicians trained in Carnatic music for more than five years (n = 18) and age-matched non-musicians (n = 33). Addenbrooke cognitive examination-III, Hindi mental status examination, and trail-making test-B (TMT-B) were used to assess cognitive functioning. A Generalized Linear Regression Model was performed including covariates such as gender, age, and years of education. We also looked at the available brain magnetic resonance imaging data of a subset of our study population to inspect the volumetric differences between musicians and non-musicians.
UNASSIGNED: Our results showed that musicians had significantly better visuospatial abilities as compared to non-musicians (P = 0.043). Musicians (130.89 ± 45.16 s) also took less time to complete the TMT-B task than non-musicians (148.73 ± 39.65 s), although it was not a statistically significant difference (P =0.150). In addition, brain imaging data suggested that musicians had increased gray matter volumes in the right precuneus, right post-central gyrus, right medial and superior frontal gyrus, right orbital gyrus, left middle temporal gyrus, left cuneus, left fusiform gyrus, and bilateral cingulate gyrus.
UNASSIGNED: Our findings are indicative of music being an important attribute in improving cognitive reserve and predicting cognitive resilience. These findings pave the way to explore the utility of non-pharmacological interventions, such as Music Therapy (especially Carnatic music in the Indian context), as a potential factor for improving cognitive reserve in elderly individuals.
摘要：
■衰老是一个自然过程，通常与认知障碍的发生率增加有关。体育锻炼,饮食，和休闲活动(音乐，舞蹈,和艺术）是有助于健康衰老的一些生活方式因素。本研究旨在探讨一生中参与音乐活动的衰老个体与未参与音乐活动的衰老个体之间的认知功能差异。
■从Tata老龄化纵向研究队列中选择居住在城市地区的51名健康老年人（50-80岁）进行研究。参与者分为两组：在Carnatic音乐中接受过五年以上培训的活跃音乐家（n=18）和年龄匹配的非音乐家（n=33）。Addenbrooke认知检查-III,印地语精神状态检查，和跟踪测试B（TMT-B）用于评估认知功能。进行了广义线性回归模型，包括性别等协变量，年龄,和多年的教育。我们还查看了我们研究人群子集的可用脑磁共振成像数据，以检查音乐家和非音乐家之间的体积差异。
■我们的结果表明，与非音乐家相比，音乐家的视觉空间能力明显更好（P=0.043）。音乐家(130.89±45.16s)完成TMT-B任务的时间也比非音乐家(148.73±39.65s)少,虽然差异无统计学意义(P=0.150)。此外,大脑成像数据表明，音乐家在右前叶增加了灰质体积，右中央后回,右内侧和上额回,右眶回,左颞中回,离开了库尼乌斯,左梭状回,和双侧扣带回。
■我们的发现表明音乐是提高认知储备和预测认知弹性的重要属性。这些发现为探索非药物干预的效用铺平了道路，例如音乐疗法（尤其是印度背景下的卡纳提音乐），作为改善老年人认知储备的潜在因素。
■从Tata老龄化纵向研究队列中选择居住在城市地区的51名健康老年人（50-80岁）进行研究。参与者分为两组：在Carnatic音乐中接受过五年以上培训的活跃音乐家（n=18）和年龄匹配的非音乐家（n=33）。Addenbrooke认知检查-III,印地语精神状态检查，和跟踪测试B（TMT-B）用于评估认知功能。进行了广义线性回归模型，包括性别等协变量，年龄,和多年的教育。我们还查看了我们研究人群子集的可用脑磁共振成像数据，以检查音乐家和非音乐家之间的体积差异。
■我们的结果表明，与非音乐家相比，音乐家的视觉空间能力明显更好（P=0.043）。音乐家(130.89±45.16s)完成TMT-B任务的时间也比非音乐家(148.73±39.65s)少,虽然差异无统计学意义(P=0.150)。此外,大脑成像数据表明，音乐家在右前叶增加了灰质体积，右中央后回,右内侧和上额回,右眶回,左颞中回,离开了库尼乌斯,左梭状回,和双侧扣带回。
■我们的发现表明音乐是提高认知储备和预测认知弹性的重要属性。这些发现为探索非药物干预的效用铺平了道路，例如音乐疗法（尤其是印度背景下的卡纳提音乐），作为改善老年人认知储备的潜在因素。
