PDF(Pubmed)
Abstract：
UNASSIGNED: Cardiometabolic disease is skyrocketing to epidemic proportions due to the high prevalence of its components and the aging of the worldwide population. More efforts are needed to improve cardiometabolic health. The aim of this nationally representative study based on the China Health and Retirement Longitudinal Study (CHARLS, 2014-2018) was to examine the association between reproductive factors and cardiometabolic disease among Chinese women aged ≥45 years.
UNASSIGNED: The CHARLS is an ongoing longitudinal study initiated in 2011, and the latest follow-up was completed in 2018. In total, 6,407 participants were analyzed. Effect-sizes are expressed as odds ratios (OR) and 95% confidence intervals (CI). Confounding was considered from statistical adjustment, subsidiary exploration, and unmeasured confounding assessment aspects.
UNASSIGNED: Of 6,407 accessible participants, 60.9% were recorded as having one or more of five predefined cardiovascular or metabolic disorders. Compared to those with two children, participants who had 0-1 child were found to have a lower risk of cardiometabolic disease (OR = 0.844, 95% CI: 0.714-0.998), and those who had ≥3 children had a greater risk (OR = 1.181, 95% CI: 1.027-1.357). Age at menarche of 16-18 years was a protective factor compared with ≤16 years of age (OR = 0.858, 95% CI: 0.749-0.982). In contrast, participants with a history of abortion were 1.212 times more likely to have cardiometabolic disorders (OR = 1.212, 95% CI: 1.006-1.465). The likelihood for the presence of unmeasured confounding was low, as reflected by E-values.
UNASSIGNED: Our findings demonstrate that number of children, age at menarche, and history of abortion were associated with a significant risk of cardiometabolic disease among Chinese women aged ≥45 years.
UNASSIGNED: The CHARLS is an ongoing longitudinal study initiated in 2011, and the latest follow-up was completed in 2018. In total, 6,407 participants were analyzed. Effect-sizes are expressed as odds ratios (OR) and 95% confidence intervals (CI). Confounding was considered from statistical adjustment, subsidiary exploration, and unmeasured confounding assessment aspects.
UNASSIGNED: Of 6,407 accessible participants, 60.9% were recorded as having one or more of five predefined cardiovascular or metabolic disorders. Compared to those with two children, participants who had 0-1 child were found to have a lower risk of cardiometabolic disease (OR = 0.844, 95% CI: 0.714-0.998), and those who had ≥3 children had a greater risk (OR = 1.181, 95% CI: 1.027-1.357). Age at menarche of 16-18 years was a protective factor compared with ≤16 years of age (OR = 0.858, 95% CI: 0.749-0.982). In contrast, participants with a history of abortion were 1.212 times more likely to have cardiometabolic disorders (OR = 1.212, 95% CI: 1.006-1.465). The likelihood for the presence of unmeasured confounding was low, as reflected by E-values.
UNASSIGNED: Our findings demonstrate that number of children, age at menarche, and history of abortion were associated with a significant risk of cardiometabolic disease among Chinese women aged ≥45 years.
摘要：
■由于其组成部分的高患病率和全球人口的老龄化，心脏代谢疾病正在飙升至流行病的比例。需要更多的努力来改善心脏代谢健康。这项具有全国代表性的研究的目的是基于中国健康与退休纵向研究(CHARLS，2014-2018）是在年龄≥45岁的中国女性中检查生殖因素与心脏代谢疾病之间的关联。
■CHARLS是一项正在进行的纵向研究，始于2011年，最新的随访于2018年完成。总的来说,对6,407名参与者进行了分析。效果大小表示为优势比(OR)和95%置信区间(CI)。混淆是从统计调整中考虑的，子公司勘探,和未测量的混杂评估方面。
■在6,407名无障碍参与者中，60.9%被记录为患有五种预定义的心血管或代谢紊乱中的一种或多种。与有两个孩子的人相比，发现有0-1名儿童的参与者患心脏代谢疾病的风险较低（OR=0.844，95％CI：0.714-0.998），那些有≥3个孩子的人有更大的风险(OR=1.181,95%CI:1.027-1.357).初潮年龄16-18岁是保护因素，与≤16岁相比（OR=0.858，95％CI：0.749-0.982）。相比之下,有流产史的参与者患心脏代谢紊乱的可能性增加1.212倍(OR=1.212,95%CI:1.006~1.465).存在无法测量的混杂因素的可能性很低，正如E值所反映的那样。
■我们的研究结果表明，儿童的数量，初潮年龄,在年龄≥45岁的中国女性中,流产史与心脏代谢疾病的显著风险相关.
■CHARLS是一项正在进行的纵向研究，始于2011年，最新的随访于2018年完成。总的来说,对6,407名参与者进行了分析。效果大小表示为优势比(OR)和95%置信区间(CI)。混淆是从统计调整中考虑的，子公司勘探,和未测量的混杂评估方面。
■在6,407名无障碍参与者中，60.9%被记录为患有五种预定义的心血管或代谢紊乱中的一种或多种。与有两个孩子的人相比，发现有0-1名儿童的参与者患心脏代谢疾病的风险较低（OR=0.844，95％CI：0.714-0.998），那些有≥3个孩子的人有更大的风险(OR=1.181,95%CI:1.027-1.357).初潮年龄16-18岁是保护因素，与≤16岁相比（OR=0.858，95％CI：0.749-0.982）。相比之下,有流产史的参与者患心脏代谢紊乱的可能性增加1.212倍(OR=1.212,95%CI:1.006~1.465).存在无法测量的混杂因素的可能性很低，正如E值所反映的那样。
■我们的研究结果表明，儿童的数量，初潮年龄,在年龄≥45岁的中国女性中,流产史与心脏代谢疾病的显著风险相关.
