PDF(Pubmed)
Abstract：
UNASSIGNED: In addition to the well-known Whipple\'s disease (WD), Tropheryma Whipplei (TW) can also lead to acute pneumonia. There is no unified consensus on the susceptible population, pathogenesis, clinical manifestations, diagnostic criteria, and treatment options for TW pneumonia.
UNASSIGNED: This is an elderly patient with multiple injuries caused by falling from a building, and was transferred to intensive care unit (ICU) for mechanical ventilation and empirical anti-infection treatment due to severe pneumonia, and then the results of targeted next-generation sequencing (tNGS) in patient\'s bronchoalveolar lavage fluid (BALF) suggested TW and human metapneumovirus (HMPV) infection, and after switching to anti-infective therapy for TW, the patient was successfully extubated and transferred out of the ICU.
UNASSIGNED: This is the first case of using tNGS to diagnose severe pneumonia caused by TW and HMPV. We hope that our study can serve as a reference for the diagnosis and treatment of related cases in the future.
UNASSIGNED: This is an elderly patient with multiple injuries caused by falling from a building, and was transferred to intensive care unit (ICU) for mechanical ventilation and empirical anti-infection treatment due to severe pneumonia, and then the results of targeted next-generation sequencing (tNGS) in patient\'s bronchoalveolar lavage fluid (BALF) suggested TW and human metapneumovirus (HMPV) infection, and after switching to anti-infective therapy for TW, the patient was successfully extubated and transferred out of the ICU.
UNASSIGNED: This is the first case of using tNGS to diagnose severe pneumonia caused by TW and HMPV. We hope that our study can serve as a reference for the diagnosis and treatment of related cases in the future.
摘要：
■除了众所周知的Whipple病（WD）之外，TropherymaWhipplei（TW）也可导致急性肺炎。易感人群没有统一的共识,发病机制，临床表现，诊断标准,以及TW肺炎的治疗选择。
■这是一名因从建筑物坠落而多处受伤的老年患者，并因重症肺炎转入重症监护病房（ICU）进行机械通气和经验性抗感染治疗，然后患者支气管肺泡灌洗液（BALF）中的靶向下一代测序（tNGS）结果提示TW和人偏肺病毒（HMPV）感染，在改用抗感染治疗TW后，患者成功拔管并转出ICU.
■这是使用tNGS诊断由TW和HMPV引起的严重肺炎的第一例。希望我们的研究能为今后相关病例的诊治提供参考。
■这是一名因从建筑物坠落而多处受伤的老年患者，并因重症肺炎转入重症监护病房（ICU）进行机械通气和经验性抗感染治疗，然后患者支气管肺泡灌洗液（BALF）中的靶向下一代测序（tNGS）结果提示TW和人偏肺病毒（HMPV）感染，在改用抗感染治疗TW后，患者成功拔管并转出ICU.
■这是使用tNGS诊断由TW和HMPV引起的严重肺炎的第一例。希望我们的研究能为今后相关病例的诊治提供参考。
