Abstract：
OBJECTIVE: Early-onset colorectal cancer (EOCRC) patients are more likely to have advanced disease and undergo more aggressive treatment modalities. However, current literature investigating the health-related quality of life (HRQoL) of EOCRC patients is scarce. This study aimed to determine the HRQoL of an Australian cohort of EOCRC patients including a subset who underwent pelvic exenteration (PE) or cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
METHODS: A cross-sectional study of EOCRC patients treated at the Royal Prince Alfred Hospital, Sydney Australia was performed. Patients were divided into groups based on the time interval from their index operation: ≤2 years and >2 years. HRQoL was evaluated using the SF-36v2 questionnaire.
RESULTS: A total of 50 patients were included. For patients ≤2 years from surgery, the median physical component summary (PCS) and mental health component summary (MCS) scores were 53.3 (36.4-58.9) and 47.3 (37.5-55.7). In the >2 years group, the median PCS and MCS scores were 50.6 (43.3-57.7) and 50.2 (39.04-56.2), respectively. Stage I (vs. stage II) disease and emergency (vs. elective) surgery conferred poorer PCS scores in patients ≤2 years from surgery. No other variables impacted PCS or MCS scores in EOCRC patients in either group.
CONCLUSIONS: HRQoL of EOCRC patients was equivocal to the Australian population. Having an earlier stage of diagnosis and emergency index operation was associated with poorer levels of physical functioning in patients ≤2 years from surgery. However, because of the limitations of this study, these findings require validation in future large-scale prospective research.
METHODS: A cross-sectional study of EOCRC patients treated at the Royal Prince Alfred Hospital, Sydney Australia was performed. Patients were divided into groups based on the time interval from their index operation: ≤2 years and >2 years. HRQoL was evaluated using the SF-36v2 questionnaire.
RESULTS: A total of 50 patients were included. For patients ≤2 years from surgery, the median physical component summary (PCS) and mental health component summary (MCS) scores were 53.3 (36.4-58.9) and 47.3 (37.5-55.7). In the >2 years group, the median PCS and MCS scores were 50.6 (43.3-57.7) and 50.2 (39.04-56.2), respectively. Stage I (vs. stage II) disease and emergency (vs. elective) surgery conferred poorer PCS scores in patients ≤2 years from surgery. No other variables impacted PCS or MCS scores in EOCRC patients in either group.
CONCLUSIONS: HRQoL of EOCRC patients was equivocal to the Australian population. Having an earlier stage of diagnosis and emergency index operation was associated with poorer levels of physical functioning in patients ≤2 years from surgery. However, because of the limitations of this study, these findings require validation in future large-scale prospective research.
摘要：
目的：早发性结直肠癌（EOCRC）患者更可能患有晚期疾病，并接受更积极的治疗方式。然而,目前研究EOCRC患者健康相关生活质量(HRQoL)的文献很少.这项研究旨在确定澳大利亚EOCRC患者队列的HRQoL，其中包括接受盆腔切除术（PE）或细胞减灭术（CRS）和腹腔热化疗（HIPEC）的子集。
方法：在皇家阿尔弗雷德王子医院接受治疗的EOCRC患者的横断面研究，澳大利亚悉尼演出。患者根据其指标手术的时间间隔分为：≤2年和>2年。使用SF-36v2问卷评估HRQoL。
结果：共纳入50例患者。对于手术后≤2年的患者，身体成分汇总(PCS)和心理健康成分汇总(MCS)评分中位数分别为53.3(36.4~58.9)和47.3(37.5~55.7).在>2年组中，PCS和MCS评分中位数分别为50.6（43.3-57.7）和50.2（39.04-56.2），分别。第一阶段(vs.II期)疾病和急诊(vs.选择性）手术后≤2年的患者的PCS评分较差。两组中的EOCRC患者均无其他变量影响PCS或MCS评分。
结论：EOCRC患者的HRQoL对澳大利亚人群是模棱两可的。在手术后≤2年的患者中，诊断和紧急指数手术的早期阶段与身体功能水平较差有关。然而,由于这项研究的局限性，这些发现需要在未来的大规模前瞻性研究中得到验证.
方法：在皇家阿尔弗雷德王子医院接受治疗的EOCRC患者的横断面研究，澳大利亚悉尼演出。患者根据其指标手术的时间间隔分为：≤2年和>2年。使用SF-36v2问卷评估HRQoL。
结果：共纳入50例患者。对于手术后≤2年的患者，身体成分汇总(PCS)和心理健康成分汇总(MCS)评分中位数分别为53.3(36.4~58.9)和47.3(37.5~55.7).在>2年组中，PCS和MCS评分中位数分别为50.6（43.3-57.7）和50.2（39.04-56.2），分别。第一阶段(vs.II期)疾病和急诊(vs.选择性）手术后≤2年的患者的PCS评分较差。两组中的EOCRC患者均无其他变量影响PCS或MCS评分。
结论：EOCRC患者的HRQoL对澳大利亚人群是模棱两可的。在手术后≤2年的患者中，诊断和紧急指数手术的早期阶段与身体功能水平较差有关。然而,由于这项研究的局限性，这些发现需要在未来的大规模前瞻性研究中得到验证.
