Abstract：
This review article provides a comprehensive overview of the advancements in using nanosuspensions for controlled drug delivery in ophthalmology. It highlights the significance of ophthalmic drug delivery due to the prevalence of eye diseases and delves into various aspects of this field. The article explores molecular mechanisms, drugs used, and physiological factors affecting drug absorption. It also addresses challenges in treating both anterior and posterior eye segments and investigates the role of mucus in obstructing micro- and nanosuspensions. Nanosuspensions are presented as a promising approach to enhance drug solubility and absorption, covering formulation, stability, properties, and functionalization. The review discusses the pros and cons of using nanosuspensions for ocular drug delivery and covers their structure, preparation, characterization, and applications. Several graphical representations illustrate their role in treating various eye conditions. Specific drug categories like anti-inflammatory drugs, antihistamines, glucocorticoids, and more are discussed in detail, with relevant studies. The article also addresses current challenges and future directions, emphasizing the need for improved nanosuspension stability and exploring potential technologies. Nanosuspensions have shown substantial potential in advancing ophthalmic drug delivery by enhancing solubility and absorption. This article is a valuable resource for researchers, clinicians, and pharmaceutical professionals in this field, offering insights into recent developments, challenges, and future prospects in nanosuspension use for ocular drug delivery.
摘要：
这篇综述文章提供了使用纳米混悬剂在眼科控制药物递送方面的进展的全面概述。它强调了由于眼部疾病的流行而导致的眼科药物递送的重要性，并深入研究了该领域的各个方面。本文探讨了分子机制，使用的药物，影响药物吸收的生理因素。它还解决了治疗前和后眼节的挑战，并研究了粘液在阻塞微米和纳米悬浮液中的作用。纳米混悬剂被认为是增强药物溶解度和吸收的一种有前途的方法。覆盖配方，稳定性,属性,和功能化。该综述讨论了使用纳米混悬剂进行眼部药物递送的利弊，并涵盖了它们的结构，准备,表征，和应用。几个图形表示说明了它们在治疗各种眼部疾病中的作用。特定的药物类别，如抗炎药，抗组胺药,糖皮质激素,并详细讨论了更多内容，相关研究。本文还讨论了当前的挑战和未来的方向，强调需要改进纳米悬浮稳定性并探索潜在技术。总之,纳米混悬剂在通过增强溶解度和吸收来推进眼科药物递送方面具有相当大的潜力。这篇文章是研究人员的宝贵资源，临床医生,以及该领域的制药专业人员，提供对最近事态发展的见解，挑战,纳米混悬剂用于眼部药物递送的未来前景。
