PDF(Pubmed)
Abstract：
Mild cognitive impairment (MCI) marks the initial phase of memory decline or other cognitive functions like language or spatial perception, while individuals typically retain the capacity to carry out everyday tasks independently. Our comprehensive article investigates the intricate landscape of cognitive disorders, focusing on MCI and Alzheimer\'s disease (AD) and Alzheimer\'s disease-related dementias (ADRD). The study aims to understand the signs of MCI, early Alzheimer\'s disease, and healthy brain aging while assessing factors influencing disease progression, pathology development and susceptibility. A systematic literature review of over 100 articles was conducted, emphasizing MCI, AD and ADRD within the elderly populations. The synthesis of results reveals significant findings regarding ethnicity, gender, lifestyle, comorbidities, and diagnostic tools. Ethnicity was found to influence MCI prevalence, with disparities observed across diverse populations. Gender differences were evident in cognitive performance and decline, highlighting the need for personalized management strategies. Lifestyle factors and comorbidities were identified as crucial influencers of cognitive health. Regarding diagnostic tools, the Montreal Cognitive Assessment (MoCA) emerged as superior to the Mini-Mental State Examination (MMSE) in early MCI detection. Overall, our article provides insights into the multifaceted nature of cognitive disorders, emphasizing the importance of tailored interventions and comprehensive assessment strategies for effective cognitive health management.
摘要：
轻度认知障碍（MCI）标志着记忆衰退或其他认知功能（如语言或空间感知）的初始阶段，而个人通常保留独立执行日常任务的能力。我们的综合文章调查了认知障碍的复杂景观，重点关注MCI和阿尔茨海默病（AD）和阿尔茨海默病相关痴呆（ADRD）。该研究旨在了解MCI，早期阿尔茨海默病，和健康的大脑老化，同时评估影响疾病进展的因素，病理学发展和易感性。对100余篇文献进行了系统的文献综述，强调老年人群的MCI、AD和ADRD。综合结果揭示了关于种族的重要发现，性别,生活方式,合并症,和诊断工具。种族被发现影响MCI患病率，在不同的人群中观察到差异。性别差异在认知表现和下降方面很明显，强调个性化管理策略的必要性。生活方式因素和合并症被确定为认知健康的关键影响因素。关于诊断工具，在早期MCI检测中,蒙特利尔认知评估(MoCA)优于简易精神状态检查(MMSE).总的来说,我们的文章提供了对认知障碍的多面性的见解，强调量身定制的干预措施和综合评估策略对于有效的认知健康管理的重要性。
