发现 9H - 嘧啶并 [4, 5 - b] 吲哚衍生物作为双重 RET / TRKA 抑制剂。
关键词: Drug discovery Kinase Medicinal chemistry Polypharmacology RET Small molecule TRK
Mesh : Humans Antineoplastic Agents / pharmacology chemistry chemical synthesis Cell Line, Tumor Drug Discovery Indoles / chemistry pharmacology chemical synthesis Molecular Structure Protein Kinase Inhibitors / pharmacology chemistry chemical synthesis Proto-Oncogene Proteins c-ret / antagonists & inhibitors metabolism Pyrimidines / chemistry pharmacology chemical synthesis Receptor, trkA / antagonists & inhibitors metabolism Structure-Activity Relationship
来 源:
DOI:10.1016/j.bmc.2024.117749
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