PDF(Pubmed)
Abstract：
This prospective birth cohort study evaluated the association of exposure to PM2.5 (diameter ≤2.5 μm), PM1-2.5 (1-2.5 μm), and PM1 (≤1 μm) with maternal thyroid autoimmunity and function during early pregnancy. A total of 15,664 pregnant women were included at 6 to 13+6 gestation weeks in China from 2018 to 2020. Single-pollutant models using generalized linear models (GLMs) showed that each 10 μg/m3 increase in PM2.5 and PM1-2.5 was related with 6% (odds ratio [OR] = 1.06, 95% confidence interval [CI]: 1.01, 1.12) and 15% (OR = 1.15, 95% CI: 1.08, 1.22) increases in the risk of thyroid autoimmunity, respectively. The odds of thyroid autoimmunity significantly increased with each interquartile range increase in PM2.5 and PM1-2.5 exposure (P for trend <0.001). PM1 exposure was not significantly associated with thyroid autoimmunity. GLM with natural cubic splines demonstrated that increases in PM2.5 and PM1-2.5 exposure were associated with lower maternal FT4 levels, while a negative association between PM1 and FT4 levels was found when exposure exceeded 32.13 μg/m3. Only PM2.5 exposure was positively associated with thyrotropin (TSH) levels. Our findings suggest that high PM exposure is associated with maternal thyroid disruption during the early pregnancy.
摘要：
这项前瞻性出生队列研究评估了PM2.5（直径≤2.5μm）暴露的相关性，PM1-2.5(1-2.5μm),和PM1（≤1μm）与妊娠早期母体甲状腺自身免疫和功能有关。从2018年到2020年，中国共有15664名孕妇在6至13+6孕周被纳入。使用广义线性模型（GLMs）的单污染物模型表明，PM2.5和PM1-2.5每增加10μg/m3，与甲状腺自身免疫风险增加6％（比值比[OR]=1.06，95％置信区间[CI]：1.01，1.12）和15％（OR=1.15，95％CI：1.08，1.22）相关，分别。随着PM2.5和PM1-2.5暴露的四分位间距增加，甲状腺自身免疫的几率显着增加（P<0.001）。PM1暴露与甲状腺自身免疫无显著相关性。GLM与自然立方样条表明，PM2.5和PM1-2.5暴露的增加与较低的母体FT4水平有关，而当暴露量超过32.13μg/m3时，发现PM1和FT4水平之间呈负相关。只有PM2.5暴露与促甲状腺激素（TSH）水平呈正相关。我们的研究结果表明，在妊娠早期，高PM暴露与母体甲状腺功能紊乱有关。
