Abstract：
Hand-arm vibration is a common occupational exposure that causes neurological impairment, myalgia, and vibration-induced Raynaud\'s phenomena or vibration white fingers (VWF). The pathological mechanism is largely unknown, though several mechanisms have been proposed, involving both immunological vascular damage and defective neural responses. The aim of this study was to test whether the substances interleukin-33 (IL-33), macrophage-derived chemokine (MDC), interleukin-10 (IL-10), endothelin-1 (ET-1), C-C motif chemokine ligand 20 (CCL20), calcitonin, and thromboxane (TXA2) changed before and after occupational hand-arm vibration exposure. 38 full-time shift workers exposed to hand-arm vibration were recruited. All the participants underwent medical examinations regarding symptoms of Raynaud\'s phenomena. In 29 of the participants, the concentration of IL-33, MDC, IL-10, ET-1, CCL20, calcitonin, and TXA2 was measured before and after a workday. There was a significant increase in ET-1 and calcitonin concentration and a decrease in the CCL20 concentration after the work shift in all participants. In the group suffering from VWF, but not in the non-VWF group, MDC was statistically significantly lower before the work shift (p = .023). The VWF group also showed a significant increase in MDC after the work shift. Exposure to occupational hand-arm vibration is associated with changes in ET-1, calcitonin, and MDC concentration in subjects suffering from vibration white fingers, suggesting a role of these biomarkers in the pathophysiology of this condition.
摘要：
手臂振动是一种常见的职业暴露，会导致神经功能缺损，肌痛，和振动引起的雷诺现象或振动白手指（VWF）。病理机制在很大程度上是未知的，尽管已经提出了几种机制，涉及免疫血管损伤和有缺陷的神经反应。这项研究的目的是测试物质白细胞介素-33（IL-33），巨噬细胞源性趋化因子（MDC），白细胞介素-10（IL-10），内皮素-1(ET-1),C-C基序趋化因子配体20（CCL20），降钙素,和血栓素（TXA2）在职业性手臂振动暴露前后发生变化。招募了38名暴露于手臂振动的全职轮班工人。所有参与者都接受了关于雷诺现象症状的医学检查。在29名参与者中，IL-33，MDC，IL-10,ET-1,CCL20,降钙素,和TXA2测量之前和之后的一个工作日。所有参与者轮班后，ET-1和降钙素浓度显着增加，CCL20浓度降低。在患有VWF的人群中，但不是在非VWF组中，工作班前MDC在统计学上显著降低(p=.023)。VWF组工作轮班后MDC也显示出显着增加。暴露于职业性手臂振动与ET-1，降钙素，和MDC集中在患有白色手指振动的受试者中，提示这些生物标志物在这种情况的病理生理学中的作用。
