PDF(Pubmed)
Abstract：
BACKGROUND: Many studies have indicated that negative emotions and personality traits are related to psoriasis, though few have provided causal evidence.
METHODS: Our analysis utilized 15 genome-wide association study datasets to identify instrumental variables associated with negative emotions, personality traits and psoriasis vulgaris. Two-sample Mendelian randomization was conducted to identify the causal associations of negative emotions and personality traits with psoriasis vulgaris. To mitigate bias from multiple tests, we adjusted p-values using the Benjamini-Hochberg method.
RESULTS: Our study revealed causal links between negative emotions and psoriasis vulgaris, including depressed affect, worry too long, feeling hurt, guilty feelings, mood swings, unenthusiasm, miserableness, fed-up feelings. However, there was no significant evidence of a causal relationship between feeling lonely and psoriasis vulgaris. Additionally, personality traits including neuroticism and openness to experience were found to have causal effects on psoriasis vulgaris. However, no significant evidence supported a causal relationship between agreeableness, conscientiousness, and extraversion with psoriasis vulgaris.
CONCLUSIONS: Our findings suggest that experiencing negative emotions including depressed affect, worrying excessively, feeling hurt, guilty feelings, mood swings, lack of enthusiasm, miserableness and fed-up feelings may pose risks for psoriasis vulgaris. Additionally, neuroticism is associated with a risk of psoriasis vulgaris. Conversely, the openness trait may serve a protective role against psoriasis vulgaris.
METHODS: Our analysis utilized 15 genome-wide association study datasets to identify instrumental variables associated with negative emotions, personality traits and psoriasis vulgaris. Two-sample Mendelian randomization was conducted to identify the causal associations of negative emotions and personality traits with psoriasis vulgaris. To mitigate bias from multiple tests, we adjusted p-values using the Benjamini-Hochberg method.
RESULTS: Our study revealed causal links between negative emotions and psoriasis vulgaris, including depressed affect, worry too long, feeling hurt, guilty feelings, mood swings, unenthusiasm, miserableness, fed-up feelings. However, there was no significant evidence of a causal relationship between feeling lonely and psoriasis vulgaris. Additionally, personality traits including neuroticism and openness to experience were found to have causal effects on psoriasis vulgaris. However, no significant evidence supported a causal relationship between agreeableness, conscientiousness, and extraversion with psoriasis vulgaris.
CONCLUSIONS: Our findings suggest that experiencing negative emotions including depressed affect, worrying excessively, feeling hurt, guilty feelings, mood swings, lack of enthusiasm, miserableness and fed-up feelings may pose risks for psoriasis vulgaris. Additionally, neuroticism is associated with a risk of psoriasis vulgaris. Conversely, the openness trait may serve a protective role against psoriasis vulgaris.
摘要：
背景：许多研究表明，负面情绪和个性特征与银屑病有关，尽管很少有人提供因果证据。
方法：我们的分析利用了15个全基因组关联研究数据集来识别与负面情绪相关的工具变量，人格特质与寻常型银屑病。进行了两个孟德尔随机样本，以确定负面情绪和人格特质与寻常型牛皮癣的因果关系。为了减轻来自多个测试的偏差，我们使用Benjamini-Hochberg方法调整了p值。
结果：我们的研究揭示了负面情绪与寻常型银屑病之间的因果关系，包括抑郁情绪，担心太久,感觉受伤,内疚的感觉，情绪波动,不热情，悲惨，受够了的感觉。然而,没有明显的证据表明孤独感与寻常型银屑病之间存在因果关系.此外,包括神经质和开放经验在内的人格特质被发现对寻常型银屑病有因果影响。然而,没有重要的证据支持同意之间的因果关系，尽责,和外向性寻常型牛皮癣。
结论：我们的研究结果表明，经历包括抑郁情绪在内的负面情绪，过度担忧，感觉受伤,内疚的感觉，情绪波动,缺乏热情,痛苦和厌倦的感觉可能构成寻常型银屑病的风险。此外,神经质与寻常型银屑病的风险有关。相反，开放性特征可能对寻常型银屑病起保护作用。
方法：我们的分析利用了15个全基因组关联研究数据集来识别与负面情绪相关的工具变量，人格特质与寻常型银屑病。进行了两个孟德尔随机样本，以确定负面情绪和人格特质与寻常型牛皮癣的因果关系。为了减轻来自多个测试的偏差，我们使用Benjamini-Hochberg方法调整了p值。
结果：我们的研究揭示了负面情绪与寻常型银屑病之间的因果关系，包括抑郁情绪，担心太久,感觉受伤,内疚的感觉，情绪波动,不热情，悲惨，受够了的感觉。然而,没有明显的证据表明孤独感与寻常型银屑病之间存在因果关系.此外,包括神经质和开放经验在内的人格特质被发现对寻常型银屑病有因果影响。然而,没有重要的证据支持同意之间的因果关系，尽责,和外向性寻常型牛皮癣。
结论：我们的研究结果表明，经历包括抑郁情绪在内的负面情绪，过度担忧，感觉受伤,内疚的感觉，情绪波动,缺乏热情,痛苦和厌倦的感觉可能构成寻常型银屑病的风险。此外,神经质与寻常型银屑病的风险有关。相反，开放性特征可能对寻常型银屑病起保护作用。
