Abstract：
This study aims to investigate sex differences and risk factors for self-reported suicide attempts among Chinese Han middle-aged patients with first-episode drug-naïve (FEDN) anxious depression (AD). A total of 1796 patients with FEDN major depressive disorder were enrolled in this study, including 341 middle-aged patients with AD. We compared the prevalence, demographics, and clinical characteristics of suicide attempts between male and female patients with FEDN middle-aged AD. We also explored the risk factors for self-reported suicide attempts in this population using binary logistic regression analysis. The male/female ratio was 91/250 and the age of onset was 51.50 ± 4.13. Our results showed that there were no significant sex differences in the prevalence of self-reported suicide attempts in middle-aged patients with FEDN AD. However, we did find significant differences in several demographic and clinical characteristics between self-reported suicide attempters and non-suicide attempters. Moreover, severe anxiety, measured by the Hamilton Anxiety Rating Scale score, was identified as a risk factor for self-reported suicide attempts in female middle-aged AD patients. Additionally, elevated thyroid peroxidase antibody (TPOAb) levels were linked to self-reported suicide attempts in male AD patients. Our findings suggest that there are no significant sex differences in the prevalence of self-reported suicide attempts in this population, but there may be sex-specific risk factors for self-reported suicide attempts in middle-aged AD. Clinical psychiatrists need to pay attention to thyroid hormone levels in middle-aged anxious depression.
摘要：
本研究旨在调查中国汉族中年首发药物初治（FEDN）焦虑抑郁（AD）患者自杀企图的性别差异和危险因素。本研究共纳入1796例FEDN重度抑郁症患者，其中中年AD患者341例。我们比较了患病率，人口统计，男性和女性FEDN中年AD患者自杀未遂的临床特征。我们还使用二元逻辑回归分析探讨了该人群中自我报告自杀企图的危险因素。男女比例为91/250，发病年龄为51.50±4.13。我们的结果表明，在FEDNAD的中年患者中，自我报告的自杀未遂的患病率没有显着的性别差异。然而,我们确实发现自我报告的自杀未遂者和非自杀未遂者在几个人口统计学和临床特征方面存在显著差异.此外，严重的焦虑,通过汉密尔顿焦虑量表评分来衡量，被确定为女性中年AD患者自我报告自杀未遂的危险因素。此外,甲状腺过氧化物酶抗体(TPOAb)水平升高与男性AD患者自我报告的自杀未遂相关.我们的研究结果表明，在该人群中，自我报告的自杀未遂的患病率没有显着的性别差异，但中年AD患者自我报告的自杀未遂可能存在性别特异性危险因素.临床精神科医师需关注中年焦虑抑郁患者的甲状腺激素水平。
