PDF(Pubmed)
Abstract：
UNASSIGNED: Major depressive disorder (MDD) is partially inheritable while its mechanism is still uncertain.
UNASSIGNED: This cross-sectional study focused on gene pathways as a whole rather than polymorphisms of single genes. Deep sequencing and gene enrichment analysis based on pathways in Reactome database were obtained to reveal gene mutations.
UNASSIGNED: A total of 117 patients with MDD and 78 healthy controls were enrolled. The Digestion and Dietary Carbohydrate pathway (Carbohydrate pathway) was determined to contain 100% mutations in patients with MDD and 0 mutation in matched healthy controls.
UNASSIGNED: Findings revealed in the current study enable a better understanding of gene pathways mutations status in MDD patients, indicating a possible genetic mechanism of MDD development and a potential diagnostic or therapeutic target.
UNASSIGNED: This cross-sectional study focused on gene pathways as a whole rather than polymorphisms of single genes. Deep sequencing and gene enrichment analysis based on pathways in Reactome database were obtained to reveal gene mutations.
UNASSIGNED: A total of 117 patients with MDD and 78 healthy controls were enrolled. The Digestion and Dietary Carbohydrate pathway (Carbohydrate pathway) was determined to contain 100% mutations in patients with MDD and 0 mutation in matched healthy controls.
UNASSIGNED: Findings revealed in the current study enable a better understanding of gene pathways mutations status in MDD patients, indicating a possible genetic mechanism of MDD development and a potential diagnostic or therapeutic target.
摘要：
■重度抑郁症（MDD）是部分可遗传的，但其机制仍不确定。
■这项横断面研究的重点是整个基因途径，而不是单个基因的多态性。基于Reactome数据库中的通路进行深度测序和基因富集分析以揭示基因突变。
■共纳入117例MDD患者和78例健康对照。消化和膳食碳水化合物途径(碳水化合物途径)被确定为在MDD患者中含有100%突变,在匹配的健康对照中含有0突变。
■当前研究中揭示的发现有助于更好地了解MDD患者的基因通路突变状态，表明MDD发展的可能遗传机制和潜在的诊断或治疗靶标。
■这项横断面研究的重点是整个基因途径，而不是单个基因的多态性。基于Reactome数据库中的通路进行深度测序和基因富集分析以揭示基因突变。
■共纳入117例MDD患者和78例健康对照。消化和膳食碳水化合物途径(碳水化合物途径)被确定为在MDD患者中含有100%突变,在匹配的健康对照中含有0突变。
■当前研究中揭示的发现有助于更好地了解MDD患者的基因通路突变状态，表明MDD发展的可能遗传机制和潜在的诊断或治疗靶标。
