%0 Journal Article
%T The digestion and dietary carbohydrate pathway contains 100% gene mutations enrichment among 117 patients with major depressive disorder.
%A Zhang N
%A Li J
%A Dong Z
%A Hu Y
%A Zhong Z
%A Gong Q
%A Kuang W
%J Front Psychiatry
%V 15
%N 0
%D 2024
%M 38742130
%F 5.435
%R 10.3389/fpsyt.2024.1362612
%X <B>UNASSIGNED: </B>Major depressive disorder (MDD) is partially inheritable while its mechanism is still uncertain.<BR><B>UNASSIGNED: </B>This cross-sectional study focused on gene pathways as a whole rather than polymorphisms of single genes. Deep sequencing and gene enrichment analysis based on pathways in Reactome database were obtained to reveal gene mutations.<BR><B>UNASSIGNED: </B>A total of 117 patients with MDD and 78 healthy controls were enrolled. The Digestion and Dietary Carbohydrate pathway (Carbohydrate pathway) was determined to contain 100% mutations in patients with MDD and 0 mutation in matched healthy controls.<BR><B>UNASSIGNED: </B>Findings revealed in the current study enable a better understanding of gene pathways mutations status in MDD patients, indicating a possible genetic mechanism of MDD development and a potential diagnostic or therapeutic target.