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Abstract：
BACKGROUND: Insufficient evidence existed about the prognostic role of the advanced lung cancer inflammation index (ALI) for gastric cancer patients who underwent curative resection. The aim of this study was to identify the predictive ability of ALI for survival after curative gastrectomy.
METHODS: We retrospectively analyzed 328 gastric cancer patients who received curative gastrectomy from the database of Chongqing University Cancer Hospital, and investigated the prognostic role of the preoperative ALI compared with clinicopathological variables and other serum biomarkers, such as preoperative neutrophil-to-lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and Lymphocyte-monocyte ratio (LMR). To minimize intergroup differences, propensity score matching (PSM) analysis was employed. Additionally, we performed a meta-analysis of four cohort studies published up to October 2023 following the PRISMA guidelines.
RESULTS: In the overall cohort, patients in the low ALI group had a significantly worse overall survival compared to those in the high ALI group (P < 0.0001). Subgroup analysis identified that ALI maintained its prognostic significance across different subgroups. In addition, ROC analysis showed that ALI had a higher AUC value for 3-year overall survival compared to NLR, PLR, and LMR (0.576 vs. 0.573 vs. 0.557 vs. 0.557). Multivariate analysis indicated that ALI, other than other serum biomarkers, was an independent risk factor for decreased overall survival in GC patients following curative surgery (HR = 1.449; 95%CI: 1.028-2.045; P = 0.034). Consistently, PSM analysis supported all of these findings. The meta-analysis including 4 studies evaluating 2542 patients, confirmed the association between the low ALI and poor survival outcomes.
CONCLUSIONS: The preoperative ALI was an independent prognostic factor for survival in gastric cancer patients who underwent curative gastrectomy.
METHODS: We retrospectively analyzed 328 gastric cancer patients who received curative gastrectomy from the database of Chongqing University Cancer Hospital, and investigated the prognostic role of the preoperative ALI compared with clinicopathological variables and other serum biomarkers, such as preoperative neutrophil-to-lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and Lymphocyte-monocyte ratio (LMR). To minimize intergroup differences, propensity score matching (PSM) analysis was employed. Additionally, we performed a meta-analysis of four cohort studies published up to October 2023 following the PRISMA guidelines.
RESULTS: In the overall cohort, patients in the low ALI group had a significantly worse overall survival compared to those in the high ALI group (P < 0.0001). Subgroup analysis identified that ALI maintained its prognostic significance across different subgroups. In addition, ROC analysis showed that ALI had a higher AUC value for 3-year overall survival compared to NLR, PLR, and LMR (0.576 vs. 0.573 vs. 0.557 vs. 0.557). Multivariate analysis indicated that ALI, other than other serum biomarkers, was an independent risk factor for decreased overall survival in GC patients following curative surgery (HR = 1.449; 95%CI: 1.028-2.045; P = 0.034). Consistently, PSM analysis supported all of these findings. The meta-analysis including 4 studies evaluating 2542 patients, confirmed the association between the low ALI and poor survival outcomes.
CONCLUSIONS: The preoperative ALI was an independent prognostic factor for survival in gastric cancer patients who underwent curative gastrectomy.
摘要：
背景：关于晚期肺癌炎症指数（ALI）对行根治性切除术的胃癌患者的预后作用的证据不足。这项研究的目的是确定ALI对根治性胃切除术后生存的预测能力。
方法：我们回顾性分析了重庆大学肿瘤医院数据库中328例接受根治性胃切除术的胃癌患者，并研究了术前ALI与临床病理变量和其他血清生物标志物的预后作用，如术前中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR）和淋巴细胞-单核细胞比率（LMR）。为了最小化群体间的差异，采用倾向评分匹配(PSM)分析。此外,我们根据PRISMA指南对截至2023年10月发表的4项队列研究进行了荟萃分析.
结果：在整个队列中，与高ALI组相比,低ALI组患者的总生存期明显更差(P<0.0001).亚组分析确定ALI在不同亚组之间维持其预后意义。此外,ROC分析显示，与NLR相比，ALI的3年总生存率AUC值较高，PLR,和LMR（0.576vs.0.573vs.0.557vs.0.557).多变量分析表明，ALI，除了其他血清生物标志物，是治疗性手术后GC患者总生存率降低的独立危险因素(HR=1.449;95CI:1.028-2.045;P=0.034)。始终如一，PSM分析支持所有这些发现。荟萃分析包括4项研究评估2542例患者，证实了低ALI与不良生存结局之间的关联。
结论：术前ALI是胃癌根治术患者生存的独立预后因素。
方法：我们回顾性分析了重庆大学肿瘤医院数据库中328例接受根治性胃切除术的胃癌患者，并研究了术前ALI与临床病理变量和其他血清生物标志物的预后作用，如术前中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR）和淋巴细胞-单核细胞比率（LMR）。为了最小化群体间的差异，采用倾向评分匹配(PSM)分析。此外,我们根据PRISMA指南对截至2023年10月发表的4项队列研究进行了荟萃分析.
结果：在整个队列中，与高ALI组相比,低ALI组患者的总生存期明显更差(P<0.0001).亚组分析确定ALI在不同亚组之间维持其预后意义。此外,ROC分析显示，与NLR相比，ALI的3年总生存率AUC值较高，PLR,和LMR（0.576vs.0.573vs.0.557vs.0.557).多变量分析表明，ALI，除了其他血清生物标志物，是治疗性手术后GC患者总生存率降低的独立危险因素(HR=1.449;95CI:1.028-2.045;P=0.034)。始终如一，PSM分析支持所有这些发现。荟萃分析包括4项研究评估2542例患者，证实了低ALI与不良生存结局之间的关联。
结论：术前ALI是胃癌根治术患者生存的独立预后因素。
