Abstract：
Necroptosis has emerged as one of the crucial pathological processes involved in the regulation of cell death and inflammation in chronic obstructive pulmonary disease (COPD). Airway epithelial necroptosis is closely linked to COPD pathogenesis. Necroptotic lung cells can release damage-associated molecular patterns (DAMPs) that can initiate a robust inflammatory response. However, the underlying mechanism of necroptosis in COPD is still not clearly understood. Therefore, we aimed to explore the roles and mechanisms of receptor-interacting serine/threonine-protein kinase 1 (RIPK1)-mediated necroptosis in the regulation of inflammatory responses in COPD to provide insights into RIPK1-inhibitor drug discovery efforts and their therapeutic benefits in COPD.
摘要：
坏死性凋亡已成为慢性阻塞性肺疾病（COPD）中调节细胞死亡和炎症的关键病理过程之一。气道上皮坏死与COPD发病密切相关。坏死性肺细胞可以释放损伤相关分子模式(DAMP),其可以引发强烈的炎症反应。然而,COPD坏死性凋亡的潜在机制尚不清楚.因此,我们旨在探讨受体相互作用的丝氨酸/苏氨酸蛋白激酶1(RIPK1)介导的坏死在COPD炎症反应调节中的作用和机制,以深入了解RIPK1抑制剂药物的发现及其在COPD中的治疗效果.
