{Reference Type}: Journal Article
{Title}: The role of RIPK1 in chronic obstructive pulmonary disease.
{Author}: Tiwari A;Gautam AS;Pandey SK;Singh S;Singh RK;
{Journal}: Drug Discov Today
{Volume}: 29
{Issue}: 7
{Year}: 2024 Jul 11
{Factor}: 8.369
{DOI}: 10.1016/j.drudis.2024.104020
{Abstract}: Necroptosis has emerged as one of the crucial pathological processes involved in the regulation of cell death and inflammation in chronic obstructive pulmonary disease (COPD). Airway epithelial necroptosis is closely linked to COPD pathogenesis. Necroptotic lung cells can release damage-associated molecular patterns (DAMPs) that can initiate a robust inflammatory response. However, the underlying mechanism of necroptosis in COPD is still not clearly understood. Therefore, we aimed to explore the roles and mechanisms of receptor-interacting serine/threonine-protein kinase 1 (RIPK1)-mediated necroptosis in the regulation of inflammatory responses in COPD to provide insights into RIPK1-inhibitor drug discovery efforts and their therapeutic benefits in COPD.