PDF(Pubmed)
Abstract：
BACKGROUND: We previously reported that delayed allergenic food introduction in infancy did not increase food allergy risk until age 4 y within our prospective cohort. However, it remains unclear whether other aspects of maternal or infant diet play roles in the development of childhood food allergy.
OBJECTIVE: We examined the relationship between maternal pregnancy and infant dietary patterns and the development of food allergies until age 8 y.
METHODS: Among 1152 Singapore Growing Up in Singapore Towards healthy Outcomes study mother-infant dyads, the infant\'s diet was ascertained using food frequency questionnaires at 18 mo. Maternal dietary patterns during pregnancy were derived from 24-h diet recalls. Food allergy was determined through interviewer-administered questionnaires at regular time points from infancy to age 8 y and defined as a positive history of allergic reactions, alongside skin prick tests at 18 mo, 3, 5, and 8 y.
RESULTS: Food allergy prevalence was 2.5% (22/883) at 12 mo and generally decreased over time by 8 y (1.9%; 14/736). Higher maternal dietary quality was associated with increased risk of food allergy (P ≤ 0.016); however, odds ratios were modest. Offspring food allergy risk ≤8 y showed no associations with measures of infant diet including timing of solids/food introduction (adjusted odds ratio [aOR]: 0.90; 95% confidence interval [CI]: 0.42, 1.92), infant\'s diet quality (aOR: 0.93; 95% CI: 0.88, 0.99) or diet diversity (aOR: 0.84; 95% CI: 0.6, 1.19). Most infants (89%) were first introduced to cow milk protein within the first month of life, while egg and peanut introduction were delayed (58.3% introduced by mean age 8.8 mo and 59.8% by mean age 18.1 mo, respectively).
CONCLUSIONS: Apart from maternal diet quality showing a modest association, infant\'s allergenic food introduction, diet quality, and dietary diversity were not associated with food allergy development in this Asian pediatric population. Interventional studies are needed to evaluate the efficacy of these approaches to food allergy prevention across different populations.
OBJECTIVE: We examined the relationship between maternal pregnancy and infant dietary patterns and the development of food allergies until age 8 y.
METHODS: Among 1152 Singapore Growing Up in Singapore Towards healthy Outcomes study mother-infant dyads, the infant\'s diet was ascertained using food frequency questionnaires at 18 mo. Maternal dietary patterns during pregnancy were derived from 24-h diet recalls. Food allergy was determined through interviewer-administered questionnaires at regular time points from infancy to age 8 y and defined as a positive history of allergic reactions, alongside skin prick tests at 18 mo, 3, 5, and 8 y.
RESULTS: Food allergy prevalence was 2.5% (22/883) at 12 mo and generally decreased over time by 8 y (1.9%; 14/736). Higher maternal dietary quality was associated with increased risk of food allergy (P ≤ 0.016); however, odds ratios were modest. Offspring food allergy risk ≤8 y showed no associations with measures of infant diet including timing of solids/food introduction (adjusted odds ratio [aOR]: 0.90; 95% confidence interval [CI]: 0.42, 1.92), infant\'s diet quality (aOR: 0.93; 95% CI: 0.88, 0.99) or diet diversity (aOR: 0.84; 95% CI: 0.6, 1.19). Most infants (89%) were first introduced to cow milk protein within the first month of life, while egg and peanut introduction were delayed (58.3% introduced by mean age 8.8 mo and 59.8% by mean age 18.1 mo, respectively).
CONCLUSIONS: Apart from maternal diet quality showing a modest association, infant\'s allergenic food introduction, diet quality, and dietary diversity were not associated with food allergy development in this Asian pediatric population. Interventional studies are needed to evaluate the efficacy of these approaches to food allergy prevention across different populations.
摘要：
背景：我们以前报道过，在我们的前瞻性队列中，婴儿期延迟引入过敏食物直到4岁才增加食物过敏风险。然而,目前尚不清楚母婴饮食的其他方面是否在儿童食物过敏的发展中起作用.
目的：在这里，我们研究了母亲怀孕和婴儿饮食模式与食物过敏发展之间的关系，直到8岁。
方法：在1152个新加坡GUSTO研究中，在18个月（M）时使用食物频率问卷确定婴儿的饮食。孕妇在怀孕期间的饮食模式来自24小时饮食回忆。食物过敏是通过采访者在从婴儿期到8岁（Y）的常规时间点进行的问卷调查确定的，并定义为过敏反应的阳性病史。在M18，Y3，Y5和Y8进行皮肤点刺试验。
结果：食物过敏患病率在12个月时为2.5%（22/883），随着时间的推移，一般下降8年（1.9%；14/736）。较高的母亲饮食质量与食物过敏风险增加相关(p≤0.016)。然而,赔率比适中。直到8年的后代食物过敏风险与婴儿饮食措施没有关联，包括固体/食物引入的时间[aOR0.90（0.42-1.92）]，婴儿的饮食质量[aOR0.93（0.88-0.99）]或饮食多样性[aOR0.84（0.6-1.19）]。大多数婴儿（89%）在出生后的第一个月内首次被引入牛奶蛋白，而鸡蛋和花生的引进被推迟(58.3%的平均年龄为8.8个月，59.8%的平均年龄为18.1个月，分别)。
结论：除了母亲的饮食质量显示出适度的相关性外，婴儿过敏食物介绍，在该亚洲儿童人群中,饮食质量和饮食多样性与食物过敏的发生无关.需要进行干预研究，以评估这些方法在不同人群中预防食物过敏的功效。
目的：在这里，我们研究了母亲怀孕和婴儿饮食模式与食物过敏发展之间的关系，直到8岁。
方法：在1152个新加坡GUSTO研究中，在18个月（M）时使用食物频率问卷确定婴儿的饮食。孕妇在怀孕期间的饮食模式来自24小时饮食回忆。食物过敏是通过采访者在从婴儿期到8岁（Y）的常规时间点进行的问卷调查确定的，并定义为过敏反应的阳性病史。在M18，Y3，Y5和Y8进行皮肤点刺试验。
结果：食物过敏患病率在12个月时为2.5%（22/883），随着时间的推移，一般下降8年（1.9%；14/736）。较高的母亲饮食质量与食物过敏风险增加相关(p≤0.016)。然而,赔率比适中。直到8年的后代食物过敏风险与婴儿饮食措施没有关联，包括固体/食物引入的时间[aOR0.90（0.42-1.92）]，婴儿的饮食质量[aOR0.93（0.88-0.99）]或饮食多样性[aOR0.84（0.6-1.19）]。大多数婴儿（89%）在出生后的第一个月内首次被引入牛奶蛋白，而鸡蛋和花生的引进被推迟(58.3%的平均年龄为8.8个月，59.8%的平均年龄为18.1个月，分别)。
结论：除了母亲的饮食质量显示出适度的相关性外，婴儿过敏食物介绍，在该亚洲儿童人群中,饮食质量和饮食多样性与食物过敏的发生无关.需要进行干预研究，以评估这些方法在不同人群中预防食物过敏的功效。
