Abstract：
Accumulated reactive oxygen species (ROS) and their resultant vascular dysfunction in androgenic alopecia (AGA) hinder hair follicle survival and cause permanent hair loss. However, safe and effective strategies to rescue hair follicle viability to enhance AGA therapeutic efficiency remain challenging. Herein, we fabricated a quercetin-encapsulated (Que) and polydopamine-integrated (PDA@QLipo) nanosystem that can reshape the perifollicular microenvironment to initial hair follicle regeneration for AGA treatment. Both the ROS scavenging and angiogenesis promotion abilities of PDA@QLipo were demonstrated. In vivo assays revealed that PDA@QLipo administrated with roller-microneedles successfully rejuvenated the \"poor\" perifollicular microenvironment, thereby promoting cell proliferation, accelerating hair follicle renewal, and facilitating hair follicle recovery. Moreover, PDA@QLipo achieved a higher hair regeneration coverage of 92.5% in the AGA mouse model than minoxidil (87.8%), even when dosed less frequently. The nanosystem creates a regenerative microenvironment by scavenging ROS and augmenting neovascularity for hair regrowth, presenting a promising approach for AGA clinical treatment.
摘要：
雄激素性脱发（AGA）中积累的活性氧（ROS）及其导致的血管功能障碍阻碍了毛囊的存活并导致永久性脱发。然而,挽救毛囊活力以提高AGA治疗效率的安全有效策略仍然具有挑战性.在这里，我们制造了一个槲皮素封装(Que)和聚多巴胺整合(PDA@QLipo)的纳米系统,该系统可以重塑毛囊周微环境,以实现AGA治疗的初始毛囊再生.证明了PDA@QLipo清除ROS和促进血管生成的能力。体内试验表明，PDA@QLipo用滚轮微针成功地恢复了“不良”的卵泡周微环境，从而促进细胞增殖，加速毛囊更新，促进毛囊恢复。此外，PDA@QLipo在AGA小鼠模型中实现了92.5%的更高的毛发再生覆盖率，高于米诺地尔(87.8%)。即使剂量不那么频繁。纳米系统通过清除ROS并增强新生血管以促进头发再生，从而创造了再生微环境。为AGA临床治疗提供了一种有希望的方法。
