Abstract：
BACKGROUND: In France, migrants constitute a significant proportion of people diagnosed with HIV, hepatitis C (HCV) and B (HBV). This study estimated the prevalence of these three viruses among detainees at a French administrative detention centre (CRA), through systematic Rapid Diagnostic Test (RDT) screening.
METHODS: This prospective, single-centre, cross-sectional, pilot study included detainees at the Nîmes CRA from February to December 2022. The primary endpoint was HIV, HCV and HBV prevalence determined by RDT. Secondary outcomes were: co-infections; study acceptability, reasons for non-inclusion, causes of non-contributory samples; and concordance between serological tests and RDT.
RESULTS: Among the 350 people agreeing to participate of 726 eligible, five refused the RDT, leaving 345 analysable participants for a participation rate of 47.5% (345/726). Participants were predominantly male (90%) with an average age of 31 years. The most common country of origin was Algeria (34%). Twenty (6%) had taken drugs intravenously and 240 (70%) had had unprotected sex within a median of 4.92 [1.08; 15] months. Virus prevalence was: 0% HIV; 4.64 [2.42; 6.86] % HCV; and 2.32 [1.01; 4.52] % HBV. Eleven (73%) of the RDT HCV positive cases were confirmed serologically. RDT detected one false-positive HCV case, as an anti-HCV Ac serological test was negative. Of the eight patients with positive HBV RDT, one declined the serology testing, thus 100% (7/7) of the tested RDT positive cases were confirmed by serology.
CONCLUSIONS: The study highlighted the need to screen detainees for HIV, HCV and HBV infection and suitability of RDTs.
METHODS: This prospective, single-centre, cross-sectional, pilot study included detainees at the Nîmes CRA from February to December 2022. The primary endpoint was HIV, HCV and HBV prevalence determined by RDT. Secondary outcomes were: co-infections; study acceptability, reasons for non-inclusion, causes of non-contributory samples; and concordance between serological tests and RDT.
RESULTS: Among the 350 people agreeing to participate of 726 eligible, five refused the RDT, leaving 345 analysable participants for a participation rate of 47.5% (345/726). Participants were predominantly male (90%) with an average age of 31 years. The most common country of origin was Algeria (34%). Twenty (6%) had taken drugs intravenously and 240 (70%) had had unprotected sex within a median of 4.92 [1.08; 15] months. Virus prevalence was: 0% HIV; 4.64 [2.42; 6.86] % HCV; and 2.32 [1.01; 4.52] % HBV. Eleven (73%) of the RDT HCV positive cases were confirmed serologically. RDT detected one false-positive HCV case, as an anti-HCV Ac serological test was negative. Of the eight patients with positive HBV RDT, one declined the serology testing, thus 100% (7/7) of the tested RDT positive cases were confirmed by serology.
CONCLUSIONS: The study highlighted the need to screen detainees for HIV, HCV and HBV infection and suitability of RDTs.
摘要：
背景：在法国，移民在被诊断为艾滋病毒的人中占很大比例，丙型肝炎（HCV）和乙型肝炎（HBV）。这项研究估计了这三种病毒在法国行政拘留中心（CRA）的被拘留者中的流行率，通过系统的快速诊断测试（RDT）筛查。
方法：这种前瞻性，单中心,横截面,试点研究包括2022年2月至12月在尼姆CRA的被拘留者。主要终点是HIV,由RDT确定的HCV和HBV患病率。次要结果是：共感染；研究可接受性，不包括在内的原因，非贡献样本的原因；以及血清学测试和RDT之间的一致性。
结果：在同意参加726名符合条件的350人中，五人拒绝了RDT,留下345名可分析参与者，参与率为47.5%(345/726)。参与者主要是男性（90％），平均年龄为31岁。最常见的来源国是阿尔及利亚（34%）。20例（6%）静脉内服用药物，240例（70%）在中位数4.92[1.08;15]个月内发生无保护性行为。病毒患病率为：0％HIV;4.64[2.42;6.86]％HCV;和2.32[1.01;4.52]％HBV。11例（73％）RDTHCV阳性病例经血清学证实。RDT检测到一例HCV假阳性病例,作为抗-HCVAc血清学试验阴性。8例HBVRDT阳性患者中,一个人拒绝了血清学检测，因此，100％（7/7）的测试RDT阳性病例通过血清学证实。
结论：该研究强调了对被拘留者进行艾滋病毒筛查的必要性，HCV和HBV感染和RDT的适用性。
方法：这种前瞻性，单中心,横截面,试点研究包括2022年2月至12月在尼姆CRA的被拘留者。主要终点是HIV,由RDT确定的HCV和HBV患病率。次要结果是：共感染；研究可接受性，不包括在内的原因，非贡献样本的原因；以及血清学测试和RDT之间的一致性。
结果：在同意参加726名符合条件的350人中，五人拒绝了RDT,留下345名可分析参与者，参与率为47.5%(345/726)。参与者主要是男性（90％），平均年龄为31岁。最常见的来源国是阿尔及利亚（34%）。20例（6%）静脉内服用药物，240例（70%）在中位数4.92[1.08;15]个月内发生无保护性行为。病毒患病率为：0％HIV;4.64[2.42;6.86]％HCV;和2.32[1.01;4.52]％HBV。11例（73％）RDTHCV阳性病例经血清学证实。RDT检测到一例HCV假阳性病例,作为抗-HCVAc血清学试验阴性。8例HBVRDT阳性患者中,一个人拒绝了血清学检测，因此，100％（7/7）的测试RDT阳性病例通过血清学证实。
结论：该研究强调了对被拘留者进行艾滋病毒筛查的必要性，HCV和HBV感染和RDT的适用性。
