PDF(Pubmed)
Abstract：
OBJECTIVE: To evaluate the prevalence of chronic comorbidities according to BMI classes and assess the interplay between excess body weight and blood glucose abnormalities in increasing the risk of major chronic diseases.
METHODS: The study is based on data from the Health Search/IQVIA Health LPD Longitudinal Patient Database, an Italian general practice registry, with data obtained from electronic clinical records of 800 general practitioners throughout Italy. Data relative to the year 2018 were analyzed. The study population was classified according to BMI (normal weight, overweight, and obesity classes 1, 2 and 3) and glucose metabolism status (normoglycemia-NGT; impaired fasting glucose-IFG; diabetes mellitus-DM). Comorbidities were identified through ICD-9 CM codes.
RESULTS: Data relative to 991,917 adults were analyzed. The prevalence of overweight was 39.4%, while the prevalence of obesity was 11.1% (class 1: 7.9%, class 2: 2.3%, class 3: 0.9%). In the whole population, the prevalence of DM and IFG was 8.9% and 4.2%, respectively. Both overweight and obesity were associated with an increasing prevalence of glucose metabolism alterations and a large array of different chronic conditions, including cardio-cerebrovascular diseases, heart failure, chronic kidney disease, osteoarticular diseases, depression, sleep apnea, and neoplasms of the gastrointestinal tract. Within each BMI class, the presence of IFG, and to a greater extent DM, identified subgroups of individuals with a marked increase in the risk of concomitant chronic conditions.
CONCLUSIONS: Addressing the double burden of excess weight and hyperglycemia represents an important challenge and a healthcare priority.
METHODS: The study is based on data from the Health Search/IQVIA Health LPD Longitudinal Patient Database, an Italian general practice registry, with data obtained from electronic clinical records of 800 general practitioners throughout Italy. Data relative to the year 2018 were analyzed. The study population was classified according to BMI (normal weight, overweight, and obesity classes 1, 2 and 3) and glucose metabolism status (normoglycemia-NGT; impaired fasting glucose-IFG; diabetes mellitus-DM). Comorbidities were identified through ICD-9 CM codes.
RESULTS: Data relative to 991,917 adults were analyzed. The prevalence of overweight was 39.4%, while the prevalence of obesity was 11.1% (class 1: 7.9%, class 2: 2.3%, class 3: 0.9%). In the whole population, the prevalence of DM and IFG was 8.9% and 4.2%, respectively. Both overweight and obesity were associated with an increasing prevalence of glucose metabolism alterations and a large array of different chronic conditions, including cardio-cerebrovascular diseases, heart failure, chronic kidney disease, osteoarticular diseases, depression, sleep apnea, and neoplasms of the gastrointestinal tract. Within each BMI class, the presence of IFG, and to a greater extent DM, identified subgroups of individuals with a marked increase in the risk of concomitant chronic conditions.
CONCLUSIONS: Addressing the double burden of excess weight and hyperglycemia represents an important challenge and a healthcare priority.
摘要：
目的：根据BMI等级评估慢性合并症的患病率，并评估超重和血糖异常在增加主要慢性疾病风险中的相互作用。
方法：该研究基于健康搜索/IQVIA健康LPD纵向患者数据库的数据，意大利普通执业登记处，从意大利800名全科医生的电子临床记录中获得的数据。对2018年的相关数据进行了分析。研究人群根据BMI(正常体重，超重,和肥胖1、2和3类）和葡萄糖代谢状态（血糖正常-NGT；空腹血糖受损-IFG；糖尿病-DM）。通过ICD-9CM代码识别合并症。
结果：分析了991,917名成年人的相关数据。超重的患病率为39.4%,而肥胖的患病率为11.1%(第一类:7.9%，第二类：2.3%，第三类：0.9%）。在整个人口中，DM和IFG的患病率分别为8.9%和4.2%，分别。超重和肥胖都与葡萄糖代谢改变的患病率增加和一系列不同的慢性疾病有关。包括心脑血管疾病,心力衰竭,慢性肾病,骨关节疾病，抑郁症,睡眠呼吸暂停,和胃肠道肿瘤。在每个BMI类别中，IFG的存在，在更大程度上，DM，确定了伴随慢性病风险显着增加的个体亚组。
结论：解决超重和高血糖的双重负担是一项重要的挑战，也是医疗保健的优先事项。
方法：该研究基于健康搜索/IQVIA健康LPD纵向患者数据库的数据，意大利普通执业登记处，从意大利800名全科医生的电子临床记录中获得的数据。对2018年的相关数据进行了分析。研究人群根据BMI(正常体重，超重,和肥胖1、2和3类）和葡萄糖代谢状态（血糖正常-NGT；空腹血糖受损-IFG；糖尿病-DM）。通过ICD-9CM代码识别合并症。
结果：分析了991,917名成年人的相关数据。超重的患病率为39.4%,而肥胖的患病率为11.1%(第一类:7.9%，第二类：2.3%，第三类：0.9%）。在整个人口中，DM和IFG的患病率分别为8.9%和4.2%，分别。超重和肥胖都与葡萄糖代谢改变的患病率增加和一系列不同的慢性疾病有关。包括心脑血管疾病,心力衰竭,慢性肾病,骨关节疾病，抑郁症,睡眠呼吸暂停,和胃肠道肿瘤。在每个BMI类别中，IFG的存在，在更大程度上，DM，确定了伴随慢性病风险显着增加的个体亚组。
结论：解决超重和高血糖的双重负担是一项重要的挑战，也是医疗保健的优先事项。
