PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to evaluate the ocular characteristics associated with spontaneously high myopia in adult nonhuman primates (NHPs).
UNASSIGNED: A total of 537 eyes of 277 macaques with an average age of 18.53 ± 3.01 years (range = 5-26 years), raised in a controlled environment, were included. We measured ocular parameters, including spherical equivalent (SE), axial length (AXL), and intraocular pressure. The 45-degree fundus images centered on the macula and the disc assessed the fundus tessellation and parapapillary atrophy (PPA). Additionally, optical coherence tomography (OCT) was used to measure the thickness of the retinal nerve fiber layer (RNFL).
UNASSIGNED: The mean SE was -1.58 ± 3.71 diopters (D). The mean AXL was 18.76 ± 0.86 mm. The prevalence rate of high myopia was 17.7%. As myopia aggravated, the AXL increased (r = -0.498, P < 0.001). Compared with non-high myopia, highly myopic eyes had a greater AXL (P < 0.001), less RNFL thickness (P = 0.004), a higher incidence of PPA (P < 0.001), and elevated grades of fundus tessellation (P < 0.001). The binary logistic regression was performed, which showed PPA (odds ratio [OR] = 4.924, 95% confidence interval [CI] = 2.375-10.207, P < 0.001) and higher grades of fundus tessellation (OR = 1.865, 95% CI = 1.474-2.361, P < 0.001) were independent risk characteristics for high myopia.
UNASSIGNED: In NHPs, a higher grade of fundus tessellation and PPA were significant biomarkers of high myopia.
UNASSIGNED: The study demonstrates adult NHPs raised in conditioned rooms have a similar prevalence and highly consistent fundus changes with human beings, which strengthens the foundation for utilizing macaques as an animal model in high myopic studies.
UNASSIGNED: A total of 537 eyes of 277 macaques with an average age of 18.53 ± 3.01 years (range = 5-26 years), raised in a controlled environment, were included. We measured ocular parameters, including spherical equivalent (SE), axial length (AXL), and intraocular pressure. The 45-degree fundus images centered on the macula and the disc assessed the fundus tessellation and parapapillary atrophy (PPA). Additionally, optical coherence tomography (OCT) was used to measure the thickness of the retinal nerve fiber layer (RNFL).
UNASSIGNED: The mean SE was -1.58 ± 3.71 diopters (D). The mean AXL was 18.76 ± 0.86 mm. The prevalence rate of high myopia was 17.7%. As myopia aggravated, the AXL increased (r = -0.498, P < 0.001). Compared with non-high myopia, highly myopic eyes had a greater AXL (P < 0.001), less RNFL thickness (P = 0.004), a higher incidence of PPA (P < 0.001), and elevated grades of fundus tessellation (P < 0.001). The binary logistic regression was performed, which showed PPA (odds ratio [OR] = 4.924, 95% confidence interval [CI] = 2.375-10.207, P < 0.001) and higher grades of fundus tessellation (OR = 1.865, 95% CI = 1.474-2.361, P < 0.001) were independent risk characteristics for high myopia.
UNASSIGNED: In NHPs, a higher grade of fundus tessellation and PPA were significant biomarkers of high myopia.
UNASSIGNED: The study demonstrates adult NHPs raised in conditioned rooms have a similar prevalence and highly consistent fundus changes with human beings, which strengthens the foundation for utilizing macaques as an animal model in high myopic studies.
摘要：
■本研究旨在评估成人非人灵长类动物(NHPs)中与自发性高度近视相关的眼部特征。
■总共有537只眼的277只猕猴，平均年龄为18.53±3.01岁（范围=5-26岁），在受控环境中长大，包括在内。我们测量了眼部参数，包括球面当量(SE)，轴向长度（AXL），和眼压。以黄斑和椎间盘为中心的45度眼底图像评估了眼底细分和乳头旁萎缩（PPA）。此外,光学相干断层扫描（OCT）用于测量视网膜神经纤维层（RNFL）的厚度。
■平均SE为-1.58±3.71屈光度(D)。平均AXL为18.76±0.86mm。高度近视患病率为17.7%。随着近视加重,AXL升高(r=-0.498,P<0.001)。与非高度近视相比,高度近视的眼睛有更大的AXL（P<0.001），更少的RNFL厚度（P=0.004），PPA发生率较高（P<0.001），眼底细分等级升高（P<0.001）。进行二元逻辑回归，其中显示PPA（比值比[OR]=4.924，95％置信区间[CI]=2.375-10.207，P<0.001）和更高的眼底细分等级（OR=1.865，95％CI=1.474-2.361，P<0.001）是高度近视的独立风险特征。
■在NHPs中，较高等级的眼底细分和PPA是高度近视的重要生物标志物.
■该研究表明，在有条件的房间中饲养的成人NHP具有与人类相似的患病率和高度一致的眼底变化，这加强了在高度近视研究中利用猕猴作为动物模型的基础。
■总共有537只眼的277只猕猴，平均年龄为18.53±3.01岁（范围=5-26岁），在受控环境中长大，包括在内。我们测量了眼部参数，包括球面当量(SE)，轴向长度（AXL），和眼压。以黄斑和椎间盘为中心的45度眼底图像评估了眼底细分和乳头旁萎缩（PPA）。此外,光学相干断层扫描（OCT）用于测量视网膜神经纤维层（RNFL）的厚度。
■平均SE为-1.58±3.71屈光度(D)。平均AXL为18.76±0.86mm。高度近视患病率为17.7%。随着近视加重,AXL升高(r=-0.498,P<0.001)。与非高度近视相比,高度近视的眼睛有更大的AXL（P<0.001），更少的RNFL厚度（P=0.004），PPA发生率较高（P<0.001），眼底细分等级升高（P<0.001）。进行二元逻辑回归，其中显示PPA（比值比[OR]=4.924，95％置信区间[CI]=2.375-10.207，P<0.001）和更高的眼底细分等级（OR=1.865，95％CI=1.474-2.361，P<0.001）是高度近视的独立风险特征。
■在NHPs中，较高等级的眼底细分和PPA是高度近视的重要生物标志物.
■该研究表明，在有条件的房间中饲养的成人NHP具有与人类相似的患病率和高度一致的眼底变化，这加强了在高度近视研究中利用猕猴作为动物模型的基础。
