PDF(Pubmed)
Abstract：
BACKGROUND: Previous research has shown that levobupivacaine is as effective as bupivacaine but carries a lower risk of cardiac and central nervous system toxicity. This study explores whether levobupivacaine and bupivacaine are preferable for all patients, includ-ing those with comorbidities, particularly focusing on their effects on colonic anastomosis. The primary objective is to examine the influence of levobupivacaine and bupivacaine on colonic anastomosis. Additionally, the study will assess their impact on wound healing and their anti-adhesive properties.
METHODS: Conducted between July 28, 2022, to August 4, 2022, at the Hamidiye Animal Experiments Laboratory, this study was approved by the University Science Health, Hamidiye Animal Experiments Local Ethics Committee. This study was conducted using 21 male Sprague rats aged 16-20 weeks. The rats were allocated into three equal groups of seven each: Group C: pre-incisional isotonic; Group B: pre-incisional bupivacaine; and Group L: pre-incisional levobupivacaine. Macroscopic adhesion scores (MAS) were recorded during laparotomy and tissue samples were taken for histopathological examination and hydroxyproline levels measurement. Wound tensile strength along the middle incision line and anastomotic burst pressure were also assessed.
RESULTS: MAS was statistically significantly lower in Groups B and L compared to Group C (p<0.001). The wound histopathology score (WHS) was significantly higher in Group L than in Group B (p=0.021). Colon histopathology scores (CHSs) were also signifi-cantly higher in Group L compared to Group C (p=0.011).
CONCLUSIONS: TThe study found that bupivacaine and levobupivacaine did not significantly enhance wound healing, although le-vobupivacaine significantly improved WHS relative to bupivacaine. According to the findings of this study, levobupivacaine can enhance clinical practice by being used in patients undergoing colon anastomosis. It contributes significantly to the durability of colon anasto-mosis, has a more positive effect on wound healing compared to bupivacaine, and exhibits anti-adhesive properties. Additional clinical trials are necessary to validate these results further.
METHODS: Conducted between July 28, 2022, to August 4, 2022, at the Hamidiye Animal Experiments Laboratory, this study was approved by the University Science Health, Hamidiye Animal Experiments Local Ethics Committee. This study was conducted using 21 male Sprague rats aged 16-20 weeks. The rats were allocated into three equal groups of seven each: Group C: pre-incisional isotonic; Group B: pre-incisional bupivacaine; and Group L: pre-incisional levobupivacaine. Macroscopic adhesion scores (MAS) were recorded during laparotomy and tissue samples were taken for histopathological examination and hydroxyproline levels measurement. Wound tensile strength along the middle incision line and anastomotic burst pressure were also assessed.
RESULTS: MAS was statistically significantly lower in Groups B and L compared to Group C (p<0.001). The wound histopathology score (WHS) was significantly higher in Group L than in Group B (p=0.021). Colon histopathology scores (CHSs) were also signifi-cantly higher in Group L compared to Group C (p=0.011).
CONCLUSIONS: TThe study found that bupivacaine and levobupivacaine did not significantly enhance wound healing, although le-vobupivacaine significantly improved WHS relative to bupivacaine. According to the findings of this study, levobupivacaine can enhance clinical practice by being used in patients undergoing colon anastomosis. It contributes significantly to the durability of colon anasto-mosis, has a more positive effect on wound healing compared to bupivacaine, and exhibits anti-adhesive properties. Additional clinical trials are necessary to validate these results further.
摘要：
背景：先前的研究表明，左布比卡因与布比卡因一样有效，但心脏和中枢神经系统毒性的风险较低。这项研究探讨了左旋布比卡因和布比卡因是否对所有患者都是优选的，包括有合并症的人，特别关注它们对结肠吻合的影响。主要目的是检查左布比卡因和布比卡因对结肠吻合的影响。此外,这项研究将评估它们对伤口愈合的影响及其抗粘连特性。
方法：2022年7月28日至2022年8月4日在Hamidiye动物实验实验室进行，这项研究得到了健康科学大学的批准，Hamidiye动物实验地方伦理委员会。本研究使用21只16-20周龄的雄性Sprague大鼠进行。将大鼠分为三个相等的组，每组七个：C组：切口前等渗；B组：切口前布比卡因；和L组：切口前左布比卡因。在剖腹手术期间记录宏观粘连评分（MAS），并采集组织样本进行组织病理学检查和羟脯氨酸水平测量。还评估了沿中间切口线的伤口拉伸强度和吻合口爆裂压力。
结果：与C组相比，B组和L组的MAS在统计学上显着降低（p<0.001）。L组的伤口组织病理学评分（WHS）明显高于B组（p=0.021）。与C组相比，L组的结肠组织病理学评分（CHSs）也显着较高（p=0.011）。
结论：T研究发现布比卡因和左布比卡因并不能显著促进伤口愈合，尽管相对于布比卡因，左旋伏比卡因显着改善了WHS。根据这项研究的结果,左旋布比卡因用于结肠吻合术可以提高临床实践。它大大有助于结肠胃病的持久性，与布比卡因相比，对伤口愈合有更积极的作用，并表现出抗粘性能。需要更多的临床试验来进一步验证这些结果。
方法：2022年7月28日至2022年8月4日在Hamidiye动物实验实验室进行，这项研究得到了健康科学大学的批准，Hamidiye动物实验地方伦理委员会。本研究使用21只16-20周龄的雄性Sprague大鼠进行。将大鼠分为三个相等的组，每组七个：C组：切口前等渗；B组：切口前布比卡因；和L组：切口前左布比卡因。在剖腹手术期间记录宏观粘连评分（MAS），并采集组织样本进行组织病理学检查和羟脯氨酸水平测量。还评估了沿中间切口线的伤口拉伸强度和吻合口爆裂压力。
结果：与C组相比，B组和L组的MAS在统计学上显着降低（p<0.001）。L组的伤口组织病理学评分（WHS）明显高于B组（p=0.021）。与C组相比，L组的结肠组织病理学评分（CHSs）也显着较高（p=0.011）。
结论：T研究发现布比卡因和左布比卡因并不能显著促进伤口愈合，尽管相对于布比卡因，左旋伏比卡因显着改善了WHS。根据这项研究的结果,左旋布比卡因用于结肠吻合术可以提高临床实践。它大大有助于结肠胃病的持久性，与布比卡因相比，对伤口愈合有更积极的作用，并表现出抗粘性能。需要更多的临床试验来进一步验证这些结果。
