PDF(Pubmed)
Abstract：
Adenoid cystic carcinoma (ACC) is a rare salivary gland cancer. Still, its growth and invasion progress is slow, and its hematogenous metastasis is ACC\'s most common distant metastasis. Because of the broad expression and low background uptake of fibroblast activation protein (FAP) in tumor stroma, FAPI is considered another potential tracer of ACC in addition to FDG. In this case, we report a patient who was diagnosed with metastatic ACC liver cancer by fine needle aspiration biopsy (FNAB) and underwent PET/CT examination of [18F]FDG and [18F]FAPI-42 to find the primary cancer lesion. Finally, the primary cancer lesion was found in the left submandibular gland and was pathologically confirmed as ACC after resection.
摘要：
腺样囊性癌（ACC）是一种罕见的涎腺癌。尽管如此，它的生长和入侵进展缓慢，其血行转移是ACC最常见的远处转移。由于成纤维细胞活化蛋白（FAP）在肿瘤间质中的广泛表达和低背景摄取，除FDG外，FAPI被认为是ACC的另一种潜在示踪剂。在这种情况下,我们报告了1例患者,通过细针穿刺活检(FNAB)诊断为转移性ACC肝癌,并接受[18F]FDG和[18F]FAPI-42PET/CT检查以发现原发癌病灶.最后,原发癌病灶位于左侧下颌下腺，切除后经病理证实为ACC。
