PDF(Pubmed)
Abstract：
UNASSIGNED: To evaluate the pro-angiogenic effect of topical erythropoietin on cornea in chemical burn-injured rabbit eyes.
UNASSIGNED: The corneal alkali-burn injury was induced in 10 eyes of 10 rabbits using filter paper saturated with 1.0 mol sodium hydroxide. The eyes were categorized into the treatment group (n = 5) that received topical erythropoietin (3000 IU/mL) every 8 hr for one month versus the control group (n = 5) that received normal saline every 8 hr for one month. All eyes were treated with topical ciprofloxacin every 8 hr until corneal re-epithelialization was complete. Corneal epithelial defects, stromal opacity, and neovascularization were evaluated after the injury. At the conclusion of the study, the rabbits were euthanized and their corneas were submitted to histopathological examination.
UNASSIGNED: Baseline characteristics including the rabbits\' weight and the severity of corneal injury were comparable in two groups. Time to complete corneal re-epithelialization was 37 days in the treatment group and 45 days in the control group (P = 0.83). There was no significant difference between the groups in the rate of epithelial healing or corneal opacification. Clinical and microscopic corneal neovascularization was observed in one eye (20%) in the treatment group and two eyes (40%) in the control group (P = 0.49).
UNASSIGNED: Recombinant human erythropoietin administered topically did not induce vessel formation in rabbit corneas after chemical burn.
UNASSIGNED: The corneal alkali-burn injury was induced in 10 eyes of 10 rabbits using filter paper saturated with 1.0 mol sodium hydroxide. The eyes were categorized into the treatment group (n = 5) that received topical erythropoietin (3000 IU/mL) every 8 hr for one month versus the control group (n = 5) that received normal saline every 8 hr for one month. All eyes were treated with topical ciprofloxacin every 8 hr until corneal re-epithelialization was complete. Corneal epithelial defects, stromal opacity, and neovascularization were evaluated after the injury. At the conclusion of the study, the rabbits were euthanized and their corneas were submitted to histopathological examination.
UNASSIGNED: Baseline characteristics including the rabbits\' weight and the severity of corneal injury were comparable in two groups. Time to complete corneal re-epithelialization was 37 days in the treatment group and 45 days in the control group (P = 0.83). There was no significant difference between the groups in the rate of epithelial healing or corneal opacification. Clinical and microscopic corneal neovascularization was observed in one eye (20%) in the treatment group and two eyes (40%) in the control group (P = 0.49).
UNASSIGNED: Recombinant human erythropoietin administered topically did not induce vessel formation in rabbit corneas after chemical burn.
摘要：
■评估局部促红细胞生成素对化学烧伤损伤的兔眼角膜的促血管生成作用。
■使用1.0mol氢氧化钠饱和的滤纸在10只兔子的10只眼中引起角膜碱烧伤。将眼睛分类为每8小时接受局部促红细胞生成素(3000IU/mL)持续一个月的治疗组(n=5)与每8小时接受生理盐水持续一个月的对照组(n=5)。每8小时用环丙沙星局部治疗所有眼睛，直到完成角膜上皮再形成。角膜上皮缺损,基质不透明,损伤后评估新生血管形成。在研究结束时，对兔子实施安乐死，并对其角膜进行组织病理学检查。
■包括兔体重和角膜损伤严重程度在内的基线特征在两组中具有可比性。治疗组完成角膜上皮再形成的时间为37天，对照组为45天（P=0.83）。各组间上皮愈合率或角膜混浊率无显著差异。治疗组一只眼(20%)和对照组两只眼(40%)观察到临床和显微镜下角膜新生血管(P=0.49)。
局部施用的重组人促红细胞生成素在化学烧伤后在兔角膜中不诱导血管形成。
■使用1.0mol氢氧化钠饱和的滤纸在10只兔子的10只眼中引起角膜碱烧伤。将眼睛分类为每8小时接受局部促红细胞生成素(3000IU/mL)持续一个月的治疗组(n=5)与每8小时接受生理盐水持续一个月的对照组(n=5)。每8小时用环丙沙星局部治疗所有眼睛，直到完成角膜上皮再形成。角膜上皮缺损,基质不透明,损伤后评估新生血管形成。在研究结束时，对兔子实施安乐死，并对其角膜进行组织病理学检查。
■包括兔体重和角膜损伤严重程度在内的基线特征在两组中具有可比性。治疗组完成角膜上皮再形成的时间为37天，对照组为45天（P=0.83）。各组间上皮愈合率或角膜混浊率无显著差异。治疗组一只眼(20%)和对照组两只眼(40%)观察到临床和显微镜下角膜新生血管(P=0.49)。
局部施用的重组人促红细胞生成素在化学烧伤后在兔角膜中不诱导血管形成。
