METHODS: This is a prospective cross-sectional observational study of HIV-positive MSM at Almenara General Hospital between September 2017 and December 2018. HPV detection and typing was performed using a polymerase chain reaction technique that evaluated 21 genotypes stratified according to oncogenic risk into six low-risk and fifteen high-risk.
RESULTS: we evaluated 214 HIV-positive MSM. The overall prevalence of anal infection by papillomavirus infection was 70% (150/214). 86% (129/150) were caused by high-risk genotypes, 79% (102/129) of them were affected by a two or more-papillomavirus genotype. The most frequent high-risk genotypes were HPV-16, 31% (46/150); HPV-52, 22% (33/150); HPV-33, 21% (31/150); HPV-58, 21% (31/150) and HPV-31, 20% (30/150). In addition, HPV-18 reached 7% (10/150). The most frequent low-risk genotypes were HPV-6, 30% (45/150) and HPV-11, 29% (44/150).
CONCLUSIONS: Prevalence of anal papillomavirus infection in HIV-positive MSM is very high in the hospital investigated. Most of these infections occurs with high-risk oncogenic genotypes. Papillomavirus 16 was the most frequent high-risk genotype.
方法:这是一项针对Almenara总医院2017年9月至2018年12月HIV阳性MSM的前瞻性横断面观察性研究。使用聚合酶链反应技术进行HPV检测和分型,该技术根据致癌风险将21个基因型分为6个低风险和15个高风险。
结果:我们评估了214个HIV阳性MSM。乳头瘤病毒感染引起的肛门感染的总体患病率为70%(150/214)。86%(129/150)是由高风险基因型引起的,其中79%(102/129)受两种或两种以上乳头瘤病毒基因型的影响。最常见的高危基因型是HPV-16,31%(46/150);HPV-52,22%(33/150);HPV-33,21%(31/150);HPV-58,21%(31/150)和HPV-31,20%(30/150)。此外,HPV-18达到7%(10/150)。最常见的低风险基因型是HPV-6,30%(45/150)和HPV-11,29%(44/150)。
结论:在医院调查的HIV阳性MSM中,肛门乳头状瘤病毒感染的患病率很高。这些感染大多发生在高风险的致癌基因型。乳头状瘤病毒16是最常见的高危基因型。