Abstract：
Ethion is a class II moderately toxic organothiophosphate pesticide. The main objective of this study was to evaluate the maternal and foetal toxicity of ethion in rats. Pregnant rats were divided into 5 groups. Group I served as control. Group II, III, IV, and V were orally administered with 0.86, 1.71, 3.43, and 6.9 mg/kg of ethion respectively, from gestational day (GD) 6-19. Dams were sacrificed on GD 20. Maternal toxicity was assessed by body weight gain, foetal resorptions, oxidative stress, liver and kidney function tests, and histopathology. Foetal toxicity was assessed by physical status, gross, teratological and histopathological examination. Ethion caused dose-dependent reduction in maternal body weight gain, increased resorptions, and reduced gravid uterine weights. Elevated MDA levels and altered levels of GSH, SOD and catalase were recorded in pregnant dam serum and tissues. SGOT, SGPT, total bilirubin, urea, uric acid, and creatinine were elevated in ethion groups indicating liver and kidney toxicity. Histology of uterus revealed myometrial degeneration and mucosal gland atrophy in uterus of pregnant dams and degenerative changes in placenta. It showed histological alterations in liver, kidney, and lungs. There was reduction in the foetal body weights and placental weights, and degenerative changes in the foetal liver and kidney. Gross evaluation of foetuses showed subcutaneous hematoma. Skeletal evaluation showed partial ossification of skull bones, costal separation, and agenesis of tail vertebrae, sternebrae, metacarpals and metatarsals. The findings reveal that prenatal exposure to ethion caused maternal and foetal toxicity in rats.
摘要：
Ethion是一种II类中等毒性的有机硫代磷酸农药。这项研究的主要目的是评估乙硫磷对大鼠的母体和胎儿毒性。孕鼠分为5组。第一组作为对照。第二组,III,IV,和V分别口服0.86、1.71、3.43和6.9mg/kg乙硫磷，从妊娠日（GD）6到19。在GD20上牺牲了大坝。通过体重增加来评估母体毒性，胎儿吸收，氧化应激，肝肾功能检查,和组织病理学。胎儿毒性是通过身体状况来评估的，gross,畸形和组织病理学检查。Ethion导致母体体重增加的剂量依赖性减少，增加再吸收，减少妊娠子宫重量。MDA水平升高和GSH水平改变，在怀孕的大坝血清和组织中记录了SOD和过氧化氢酶。SGOT,SGPT,总胆红素,尿素,尿酸,乙硫离子组的肌酐升高，表明肝和肾毒性。子宫组织学显示妊娠母鼠子宫肌层变性和粘膜腺萎缩，胎盘变性。它显示了肝脏的组织学改变，肾,还有肺.胎儿体重和胎盘重量减少，胎儿肝脏和肾脏的退行性变化。胎儿的粗略评估显示皮下血肿。骨骼评估显示颅骨部分骨化，肋骨分离，和尾椎的发育不全，Sternebrae,掌骨和meta骨。研究结果表明，妊娠暴露于乙硫磷对大鼠造成母体和胎儿毒性。
