Abstract：
BACKGROUND: Bladder cancer (BC) is the seventh most common cancer worldwide. Not every infection ends as cancer, although the HPV-induced carcinogenesis is a complex process consequence of inflammation. To determine the association between human papillomavirus (HPV) and the diagnosis of bladder cancer.
METHODS: We carried out a systematic review according to Cochrane and PRISMA recommendations. We searched in EMBASE, Medline (Ovid), and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We included case-control studies. The risk of bias assessment was performed based on QUADAS2. We performed a random effect Meta-analysis.
RESULTS: We included 14 studies in qualitative and quantitative analysis. There was mainly a low risk of bias. We finally found a strong association between the presence of HPV and bladder cancer diagnosis (OR 4.18 95%CI 2.63-6.66; I2 = 40%).
CONCLUSIONS: HPV is currently associated with the diagnosis of bladder cancer.
METHODS: We carried out a systematic review according to Cochrane and PRISMA recommendations. We searched in EMBASE, Medline (Ovid), and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We included case-control studies. The risk of bias assessment was performed based on QUADAS2. We performed a random effect Meta-analysis.
RESULTS: We included 14 studies in qualitative and quantitative analysis. There was mainly a low risk of bias. We finally found a strong association between the presence of HPV and bladder cancer diagnosis (OR 4.18 95%CI 2.63-6.66; I2 = 40%).
CONCLUSIONS: HPV is currently associated with the diagnosis of bladder cancer.
摘要：
背景：膀胱癌（BC）是全球第七大最常见的癌症。不是所有的感染都以癌症结束,尽管HPV诱导的致癌作用是炎症的复杂过程。探讨人乳头瘤病毒(HPV)与膀胱癌诊断的关系。
方法：我们根据Cochrane和PRISMA的建议进行了系统评价。我们在EMBASE搜索,Medline(Ovid),和Cochrane中央控制试验登记册（CENTRAL），从开始到现在。我们纳入了病例对照研究。基于QUADAS2进行偏倚风险评估。我们进行了随机效应Meta分析。
结果：我们纳入了14项定性和定量分析研究。主要存在低偏倚风险。我们最终发现HPV的存在与膀胱癌诊断之间存在很强的相关性（OR4.1895CI2.63至6.66；I2=40％）。
结论：HPV目前与膀胱癌的诊断相关。
方法：我们根据Cochrane和PRISMA的建议进行了系统评价。我们在EMBASE搜索,Medline(Ovid),和Cochrane中央控制试验登记册（CENTRAL），从开始到现在。我们纳入了病例对照研究。基于QUADAS2进行偏倚风险评估。我们进行了随机效应Meta分析。
结果：我们纳入了14项定性和定量分析研究。主要存在低偏倚风险。我们最终发现HPV的存在与膀胱癌诊断之间存在很强的相关性（OR4.1895CI2.63至6.66；I2=40％）。
结论：HPV目前与膀胱癌的诊断相关。
