突变 p53 的年龄特异性诱导在成年小鼠中驱动克隆造血和急性髓细胞性白血病。
关键词: Mdm2 haploinsufficiency TP53 mutations acute myeloid leukemia cholesterol biosynthesis clonal hematopoiesis hematopoietic stem cells mevalonate pathway mouse model myeloid-biased hematopoiesis
Mesh : Animals Tumor Suppressor Protein p53 / genetics metabolism Leukemia, Myeloid, Acute / genetics pathology Clonal Hematopoiesis / genetics Mice Mutation / genetics Proto-Oncogene Proteins c-mdm2 / genetics metabolism Hematopoietic Stem Cells / metabolism pathology Mice, Inbred C57BL Haploinsufficiency / genetics Disease Models, Animal Hematopoiesis / genetics
来 源:
DOI:10.1016/j.xcrm.2024.101558
PDF(Pubmed)