PDF(Pubmed)
Abstract：
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production. (J Histochem Cytochem XX.XXX-XXX, XXXX).
摘要：
通过有氧糖酵解形成乳酸和ATP，Warburg效应,被认为是癌症的标志.在非癌组织的血管生成过程中，增殖茎内皮细胞（ECs）也通过有氧糖酵解产生乳酸和ATP。事实上,所有的增殖细胞，非癌细胞和癌细胞，需要乳酸用于细胞生长和组织扩张的构建块的生物合成。此外，肿瘤中的非增殖癌症干细胞和血管生成过程中的前导尖端ECs都依赖于糖酵解来产生丙酮酸，通过氧化磷酸化（OXPHOS）用于线粒体中的ATP合成。因此,有氧糖酵解不是癌症的特殊标志，而是细胞增殖的标志，限制了其在癌症治疗中的应用。然而,用糖酵解抑制剂局部治疗血管生成性眼部疾病可能是一种安全的治疗选择，值得进行实验研究。眼睛中的大多数类型的细胞，如光感受器和周细胞使用OXPHOS产生ATP，而增殖的血管生成茎ECs依赖于糖酵解来产生乳酸和ATP。（J组织学细胞化学XX。XXX-XXX,XXXX).
