PDF(Pubmed)
Abstract：
Phthalates and bisphenol A are recognized as the predominant endocrine-disrupting substances (EDCs) in the environment, but their impact on sleep health remains unclear. Vitamin D has often been reported to play a role in sleep health and may be affected by endocrine-disrupting compounds. The study utilized data from 5476 individuals in the NHANES project to investigate the correlation between combined exposure to environmental EDCs and sleep duration through modeling various exposures. Furthermore, it emphasizes the importance of vitamin D in the present scenario. Preliminary analyses suggested that vitamin D-deficient individuals generally slept shorter than individuals with normal vitamin D (p < 0.05). Exposure to Mono-ethyl phthalate (MEP), triclosan (TRS), and Mono-benzyl phthalate (MZP), either alone or in combination, was associated with reduced sleep duration and a greater risk of vitamin D deficiency. Individuals with low vitamin D levels exposed to TRS experienced shorter sleep duration than those with normal vitamin D levels (p < 0.05). TRS and MZP were identified as crucial factors in patient outcomes when evaluating mixed exposures (p < 0.05). The results provide new data supporting a link between exposure to EDCs and insufficient sleep length. Additionally, they imply that a vitamin D shortage may worsen the sleep problems induced by EDCs.
摘要：
邻苯二甲酸酯和双酚A被认为是环境中主要的内分泌干扰物质（EDCs）。但它们对睡眠健康的影响仍不清楚。据报道，维生素D在睡眠健康中起作用，并可能受到内分泌干扰化合物的影响。该研究利用了NHANES项目中5476名个体的数据，通过对各种暴露进行建模，研究了环境EDC组合暴露与睡眠持续时间之间的相关性。此外，它强调了维生素D在目前情况下的重要性。初步分析表明，缺乏维生素D的个体通常睡眠不足的个体比维生素D正常的个体（p<0.05）。接触邻苯二甲酸单乙酯（MEP），三氯生(TRS),和邻苯二甲酸单苄基酯（MZP），无论是单独还是组合，与睡眠时间减少和维生素D缺乏风险增加相关。暴露于TRS的维生素D水平低的个体的睡眠时间比维生素D水平正常的个体短（p<0.05）。在评估混合暴露时，TRS和MZP被确定为患者预后的关键因素（p<0.05）。结果提供了新的数据，支持暴露于EDC和睡眠时间不足之间的联系。此外,他们暗示维生素D缺乏可能会加剧内分泌干扰物引起的睡眠问题。
