PDF(Pubmed)
Abstract：
Modulating the gut microbiota is recognised as one strategy for preventing and fighting diseases. While the significant impact of diet on the gut microbiota\'s composition and function has been extensively researched, there is a notable lack of studies on the interactions between diet, microbiota, and helminth infections. Here, we used a combination of self-reported food intake and a 16S rDNA sequencing approach to analyse the composition of the gut microbiota in women of reproductive age from the two main islands of the Zanzibar archipelago, where helminth infections are endemic. We also applied a Spearman correlation analysis to food/nutrients and gut microbiota. Our results reveal that, despite close ethnic and cultural ties, the participants\' gut microbiota differs depending on their location. A nutrient intake analysis revealed deficiencies in minerals and vitamins, indicating an imbalanced diet. A correlation analysis identified bacterial taxa consistently correlated with specific food or nutrients in healthy women from both locations, and in two types of helminth infections. Escherichia/Shigella abundances, usually associated with Trichuris trichiura infection, consistently correlated with insufficient levels of vitamins B2 and B12. In conclusion, our findings suggest that the increased consumption of specific food like cassava and fish, as well as essential nutrients such as calcium, B vitamins, and vitamin A, may modulate the gut microbiota of populations residing in regions where helminth infections are endemic.
摘要：
调节肠道微生物群被认为是预防和对抗疾病的一种策略。虽然饮食对肠道微生物群的组成和功能的显著影响已被广泛研究，明显缺乏关于饮食之间相互作用的研究，微生物群,和蠕虫感染.这里,我们使用自我报告的食物摄入量和16SrDNA测序方法的组合来分析来自桑给巴尔群岛两个主要岛屿的育龄妇女的肠道微生物群的组成。蠕虫感染是地方性的。我们还将Spearman相关性分析应用于食物/营养素和肠道微生物群。我们的结果显示,尽管种族和文化联系紧密，参与者的肠道微生物群根据他们的位置而有所不同。营养摄入分析显示矿物质和维生素缺乏，说明饮食不平衡。相关性分析确定细菌类群与来自两个地方的健康女性的特定食物或营养素一致相关。和两种类型的蠕虫感染。大肠杆菌/志贺氏菌丰度，通常与Trichuris感染有关，始终与维生素B2和B12水平不足相关。总之,我们的研究结果表明，木薯和鱼等特定食物的消费量增加，以及钙等必需营养素，B族维生素,和维生素A,可能会调节居住在蠕虫感染流行地区的人群的肠道微生物群。
