PDF(Pubmed)
Abstract：
Diabetes mellitus (DM) is known as the first non-communicable global epidemic. It is estimated that 537 million people have DM, but the condition has been properly diagnosed in less than half of these patients. Despite numerous preventive measures, the number of DM cases is steadily increasing. The state of chronic hyperglycaemia in the body leads to numerous complications, including diabetic cardiomyopathy (DCM). A number of pathophysiological mechanisms are behind the development and progression of cardiomyopathy, including increased oxidative stress, chronic inflammation, increased synthesis of advanced glycation products and overexpression of the biosynthetic pathway of certain compounds, such as hexosamine. There is extensive research on the treatment of DCM, and there are a number of therapies that can stop the development of this complication. Among the compounds used to treat DCM are antiglycaemic drugs, hypoglycaemic drugs and drugs used to treat myocardial failure. An important element in combating DCM that should be kept in mind is a healthy lifestyle-a well-balanced diet and physical activity. There is also a group of compounds-including coenzyme Q10, antioxidants and modulators of signalling pathways and inflammatory processes, among others-that are being researched continuously, and their introduction into routine therapies is likely to result in greater control and more effective treatment of DM in the future. This paper summarises the latest recommendations for lifestyle and pharmacological treatment of cardiomyopathy in patients with DM.
摘要：
糖尿病（DM）被称为第一个非传染性的全球流行病。据估计，有5.37亿人患有DM，但是在这些患者中，只有不到一半的患者得到了正确的诊断。尽管采取了许多预防措施，DM病例数稳步增加。体内慢性高血糖的状态会导致许多并发症，包括糖尿病性心肌病（DCM）。心肌病的发展和进展背后有许多病理生理机制，包括增加的氧化应激，慢性炎症，某些化合物的高级糖基化产物的合成和生物合成途径的过度表达，如己糖胺。对DCM的处理有广泛的研究,有许多疗法可以阻止这种并发症的发展。其中用于治疗DCM的化合物是抗血糖药，降血糖药物和用于治疗心肌衰竭的药物。应对DCM的一个重要因素是健康的生活方式-均衡的饮食和体育锻炼。还有一组化合物，包括辅酶Q10，抗氧化剂和信号通路和炎症过程的调节剂，其中——正在不断研究，将其引入常规治疗可能会导致未来对DM的更大控制和更有效的治疗。本文总结了DM患者心肌病的生活方式和药物治疗的最新建议。
