PDF(Pubmed)
Abstract：
Sport injuries, including the anterior crucial ligament rupture (ACLR) seem to be related to complex genetic backgrounds, including the genes responsible for inflammatory response. This review and meta-analysis investigated the contribution of the polymorphisms of genes encoding inflammatory cytokines and their receptors to the risk of ACLR. The scientific databases Science Direct, EBSCO host, Scopus, PubMed, and Google Scholar were screened (completed on 14 June 2023) according to the established inclusion/exclusion criteria (only fully accessible, original, human case-control studies written in English concerning the effect of interleukin genes\' polymorphisms on the occurrence of ACL injury were included) and statistical meta-analysis using R version 4.0.3 was performed. The PRISMA methodology was used to review articles. The review protocol was registered under the number CRD42024514316 in the Prospero database. Eighty-nine studies were identified and narrowed down to three original case-control studies used for the meta-analysis. The studies analyzed Polish, South African, and Swedish cohorts, altogether 1282 participants. The candidate polymorphisms indicated in the studies involved IL6 rs1800795, IL6R rs2228145 and IL1B rs16944. The systematic review showed the relationships between IL6 rs1800795 polymorphism and ACLR in the Polish subpopulation, and IL6R rs2228145 and IL1B rs16944 in the South African subpopulations. The meta-analysis revealed that the IL6 rs1800795 CG genotype was over-represented (OR = 1.30, 95% CI 1.02-1.66), while the CC genotype was under-represented (OR = 0.75, 95% CI 0.54-1.03) in ACLR subjects, but no significant impact of IL6R rs2228145 was shown. Additionally, a tendency of the IL1B rs16944 CT genotype to be protective (OR 0.89, 95% CI 0.70-1.14), while the TT to be a risk genotype (OR 1.19, 95% CI 0.84-1.68) was observed. Thus, the relationship between the interleukin receptor IL6R rs2228145 and ACLR risk was not confirmed. However, the impact of genes coding pleiotropic IL6 rs1800795 on the incidences of ACLR was clear and the effect of pro-inflammatory IL1B rs16944 was possible.
摘要：
运动损伤,包括前关键韧带断裂（ACLR）似乎与复杂的遗传背景有关，包括负责炎症反应的基因。这篇综述和荟萃分析研究了编码炎性细胞因子及其受体的基因多态性对ACLR风险的贡献。科学数据库ScienceDirect,EBSCO主机，Scopus,PubMed,和谷歌学者根据既定的纳入/排除标准进行了筛选(于2023年6月14日完成)(只有完全可访问，原创,纳入了以英文撰写的关于白细胞介素基因多态性对ACL损伤发生影响的人类病例对照研究),并使用R版本4.0.3进行了统计学荟萃分析。PRISMA方法用于审查文章。审查方案在Prospero数据库中以CRD42024514316号注册。确定了89项研究，并将其缩小到用于荟萃分析的3项原始病例对照研究。研究分析了波兰人，南非,和瑞典同伙，1282人。研究中指出的候选多态性涉及IL6rs1800795、IL6Rrs2228145和IL1Brs16944。系统评价显示IL6rs1800795多态性与波兰亚群ACLR之间的关系，以及南非亚群中的IL6Rrs2228145和IL1Brs16944。荟萃分析显示IL6rs1800795CG基因型过度表达(OR=1.30,95%CI1.02-1.66),虽然CC基因型在ACLR受试者中代表性不足（OR=0.75，95％CI0.54-1.03），但未显示IL6Rrs2228145的显着影响。此外,IL1Brs16944CT基因型具有保护性的趋势(OR0.89，95%CI0.70-1.14)，而TT为风险基因型(OR1.19,95%CI0.84-1.68)。因此，白细胞介素受体IL6Rrs2228145与ACLR风险之间的关系未得到证实.然而,编码多效性IL6rs1800795的基因对ACLR发生率的影响是明确的,促炎性IL1Brs16944的作用是可能的.
