PDF(Pubmed)
Abstract：
This study investigates the efficacy of a thermo-responsive N-acetylcysteine (NAC) hydrogel on wound healing and oral ulcer recovery. Formulated by combining NAC with methylcellulose, the hydrogel\'s properties were assessed for temperature-induced gelation and cell viability using human fibroblast cells. In vivo experiments on Sprague Dawley rats compared the hydrogel\'s effects against saline, NAC solution, and a commercial NAC product. Results show that a 5% NAC and 1% methylcellulose solution exhibited optimal outcomes. While modest improvements in wound healing were observed, significant enhancements were noted in oral ulcer recovery, with histological analyses indicating fully regenerated mucosal tissue. The study concludes that modifying viscosity enhances NAC retention, facilitating tissue regeneration. These findings support previous research on the beneficial effects of antioxidant application on damaged tissues, suggesting the potential of NAC hydrogels in improving wound care and oral ulcer treatment.
摘要：
这项研究调查了热响应性N-乙酰半胱氨酸（NAC）水凝胶对伤口愈合和口腔溃疡恢复的功效。通过将NAC与甲基纤维素组合配制，使用人成纤维细胞评估水凝胶的特性，用于温度诱导的凝胶化和细胞活力。对SpragueDawley大鼠的体内实验比较了水凝胶对盐水的影响，NAC解决方案,和商业NAC产品。结果表明,5%NAC和1%甲基纤维素溶液表现出最佳结果。虽然观察到伤口愈合的适度改善，口腔溃疡恢复显着增强，组织学分析表明完全再生的粘膜组织。该研究得出结论，改性粘度增强NAC保留，促进组织再生。这些发现支持了先前关于抗氧化剂应用对受损组织的有益作用的研究，表明NAC水凝胶在改善伤口护理和口腔溃疡治疗方面的潜力。
