PDF(Pubmed)
Abstract：
Diverse secondary metabolites in plants, with their rich biological activities, have long been important sources for human medicine, food additives, pesticides, etc. However, the large-scale cultivation of host plants consumes land resources and is susceptible to pest and disease problems. Additionally, the multi-step and demanding nature of chemical synthesis adds to production costs, limiting their widespread application. In vitro cultivation and the metabolic engineering of plants have significantly enhanced the synthesis of secondary metabolites with successful industrial production cases. As synthetic biology advances, more research is focusing on heterologous synthesis using microorganisms. This review provides a comprehensive comparison between these two chassis, evaluating their performance in the synthesis of various types of secondary metabolites from the perspectives of yield and strategies. It also discusses the challenges they face and offers insights into future efforts and directions.
摘要：
植物中的各种次生代谢产物，具有丰富的生物活性，长期以来一直是人类医学的重要来源，食品添加剂,杀虫剂,等。然而,寄主植物的大规模种植消耗土地资源，容易受到病虫害的影响。此外,化学合成的多步和苛刻的性质增加了生产成本，限制了其广泛应用。通过成功的工业生产案例，体外培养和植物的代谢工程显着增强了次生代谢产物的合成。随着合成生物学的进步,更多的研究集中在利用微生物进行异源合成。这篇评论提供了这两个底盘之间的全面比较，从产量和策略的角度评估它们在各种次生代谢物合成中的性能。它还讨论了他们面临的挑战，并提供了对未来努力和方向的见解。
