PDF(Pubmed)
Abstract：
Ultraviolet radiation can heighten tyrosinase activity, stimulate melanocyte production, impede the metabolism of numerous melanocytes, and result in the accumulation of plaques on the skin surface. α-Arbutin, a bioactive substance extracted from the arbutin plant, has been widely used for skin whitening. In this study, the whitening effect of α-arbutin by inhibiting tyrosinase activity and alleviating the photoaging effect induced by UVB are investigated. The results indicate that α-arbutin can inhibit skin inflammation, and its effectiveness is positively correlated with concentration. Moreover, α-arbutin can reduce the skin epidermal thickness, decrease the number of inflammatory cells, and down-regulate the expression levels of IL-1β, IL-6 and TNF-α, which are inflammatory factors. It also promotes the expression of COL-1 collagen, thus playing an important role in anti-inflammatory action. Network pharmacology, metabolomics and transcriptomics further confirm that α-arbutin is related to the L-tyrosine metabolic pathway and may interfere with various signaling pathways related to melanin and other photoaging by regulating metabolic changes. Therefore, α-arbutin has a potential inhibitory effect on UVB-induced photoaging and possesses a whitening effect as a cosmetic compound.
摘要：
紫外线辐射可以提高酪氨酸酶的活性，刺激黑素细胞的产生，阻碍许多黑素细胞的代谢，并导致皮肤表面斑块的积累。α-熊果苷,从熊果苷植物中提取的生物活性物质，已广泛用于皮肤美白。在这项研究中,研究了α-熊果苷通过抑制酪氨酸酶活性和减轻UVB诱导的光老化效应的美白作用。结果表明，α-熊果苷可以抑制皮肤炎症，其有效性与浓度呈正相关。此外，α-熊果苷可以减少皮肤表皮厚度，减少炎症细胞的数量，并下调IL-1β的表达水平，IL-6和TNF-α,是炎症因子。它还促进COL-1胶原蛋白的表达，因此在抗炎作用中起重要作用。网络药理学,代谢组学和转录组学进一步证实,α-熊果苷与L-酪氨酸代谢途径相关,可能通过调节代谢变化干扰与黑色素和其他光老化相关的各种信号通路.因此,α-熊果苷对UVB诱导的光老化具有潜在的抑制作用，并具有作为化妆品化合物的增白作用。
