PDF(Pubmed)
Abstract：
A chemical investigation of the arils of Torreya grandis led to the isolation of seven abietane-type diterpenoids (compounds 1-7) including three previously undescribed compounds, one unreported natural product, and three known analogs. The structures of these compounds were determined by means of spectroscopy, single-crystal X-ray diffraction, and ECD spectra. An antibacterial activity assay showed that compounds 5 and 6 had significant inhibitory effects on methicillin-resistant Staphylococcus aureus, with MIC values of 100 μM. Moreover, compounds 1, 3, 4, and 7 exhibited anti-neuroinflammatory activity in LPS-stimulated BV-2 microglia cells, with the IC50 values ranging from 38.4 to 67.9 μM.
摘要：
对香葱的化学研究导致分离出七种松香烷型二萜（化合物1-7），包括三种以前未描述的化合物，一种未报告的天然产物，和三种已知的类似物。这些化合物的结构是通过光谱学来确定的，单晶X射线衍射,和ECD光谱。抑菌活性实验表明,化合物5和6对耐甲氧西林金黄色葡萄球菌有明显的抑制作用,MIC值为100μM。此外，化合物1、3、4和7在LPS刺激的BV-2小胶质细胞中表现出抗神经炎症活性,IC50值范围为38.4至67.9μM。
