{Reference Type}: Journal Article
{Title}: Abietane-Type Diterpenoids from the Arils of Torreya grandis.
{Author}: Gao Y;Yang J;Zhang Y;Gao L;Tian J;Han W;Gao J;
{Journal}: Molecules
{Volume}: 29
{Issue}: 9
{Year}: 2024 Apr 23
{Factor}: 4.927
{DOI}: 10.3390/molecules29091905
{Abstract}: A chemical investigation of the arils of Torreya grandis led to the isolation of seven abietane-type diterpenoids (compounds 1-7) including three previously undescribed compounds, one unreported natural product, and three known analogs. The structures of these compounds were determined by means of spectroscopy, single-crystal X-ray diffraction, and ECD spectra. An antibacterial activity assay showed that compounds 5 and 6 had significant inhibitory effects on methicillin-resistant Staphylococcus aureus, with MIC values of 100 μM. Moreover, compounds 1, 3, 4, and 7 exhibited anti-neuroinflammatory activity in LPS-stimulated BV-2 microglia cells, with the IC50 values ranging from 38.4 to 67.9 μM.