PDF(Pubmed)
Abstract：
Background/Objectives: Tourette Syndrome (TS), Obsessive Compulsive Disorder (OCD), and Body-Focused Repetitive Behaviors (BFRB) are three disorders that share many similarities in terms of phenomenology, neuroanatomy, and functionality. However, despite the literature pointing toward a plausible spectrum of these disorders, only a few studies have compared them. Studying the neurocognitive processes using Event-Related Potentials (ERPs) offers the advantage of assessing brain activity with excellent temporal resolution. The ERP components can then reflect specific processes known to be potentially affected by these disorders. Our first goal is to characterize \'when\' in the processing stream group differences are the most prominent. The second goal is to identify \'where\' in the brain the group discrepancies could be. Methods: Participants with TS (n = 24), OCD (n = 18), and BFRB (n = 16) were matched to a control group (n = 59) and were recorded with 58 EEG electrodes during a visual counting oddball task. Three ERP components were extracted (i.e., P200, N200, and P300), and generating sources were modelized with Standardized Low-Resolution Electromagnetic Tomography. Results: We showed no group differences for the P200 and N200 when controlling for anxiety and depressive symptoms, suggesting that the early cognitive processes reflected by these components are relatively intact in these populations. Our results also showed a decrease in the later anterior P300 oddball effect for the TS and OCD groups, whereas an intact oddball effect was observed for the BFRB group. Source localization analyses with sLORETA revealed activations in the lingual and middle occipital gyrus for the OCD group, distinguishing it from the other two clinical groups and the controls. Conclusions: It seems that both TS and OCD groups share deficits in anterior P300 activation but reflect distinct brain-generating source activations.
摘要：
背景/目标：Tourette综合征（TS），强迫症（强迫症），以身体为中心的重复行为（BFRB）是三种在现象学方面有许多相似之处的疾病，神经解剖学,和功能。然而,尽管有文献指出这些疾病的合理范围，只有少数研究将它们进行了比较。使用事件相关电位（ERP）研究神经认知过程提供了以出色的时间分辨率评估大脑活动的优势。然后，ERP组件可以反映已知可能受这些疾病影响的特定过程。我们的第一个目标是表征\'何时\'在处理流中的组差异是最突出的。第二个目标是确定小组差异可能在大脑中的位置。方法：TS参与者(n=24)，强迫症（n=18），和BFRB（n=16）与对照组（n=59）匹配，并在视觉计数怪球任务中用58个EEG电极记录。提取了三个ERP组件(即，P200、N200和P300),并使用标准化的低分辨率电磁层析成像对生成源进行建模。结果：当控制焦虑和抑郁症状时，我们没有发现P200和N200的群体差异，这表明这些组成部分反映的早期认知过程在这些人群中相对完整。我们的结果还表明，TS和OCD组的后期P300前球效应降低，而BFRB组观察到完整的奇数效应。用sLORETA进行的源定位分析显示，强迫症组的舌和枕中回激活，将其与其他两个临床组和对照组区分开来。结论：TS和OCD组似乎在前P300激活中均存在缺陷，但反映了不同的大脑生成源激活。
