PDF(Pubmed)
Abstract：
Clear cell acanthoma (CCA) and squamous cell carcinoma (SCC) represent distinct entities within dermatological oncology, each posing unique diagnostic and therapeutic challenges. CCA is a rare, benign epidermal growth, often not associated with human papillomavirus (HPV) infection, whereas SCC, a more aggressive form of skin cancer, has been linked to both ultraviolet (UV) exposure and HPV. Understanding the co-occurrence of these conditions in a single patient can enhance diagnostic accuracy and therapeutic outcomes. We report a 64-year-old male who underwent an operation for a verruciform lesion in the right groin, which was diagnosed as HPV-positive CCA alongside keratinised SCC. A literature search across January 2024 revealed limited evidence directly linking HPV to CCA, suggesting a need for further investigation. The speculative association between HPV and CCA warrants deeper exploration, especially considering the potential for HPV to contribute to lesion development through indirect mechanisms. The coexistence of CCA and SCC in an elderly patient presents a unique clinical scenario. This emphasises the need for vigilant diagnosis and tailored treatment strategies, highlighting the gap in understanding the pathogenesis of CCA, particularly its potential association with HPV. Further research is crucial for elucidating the complex interactions governing these conditions and for developing targeted interventions.
摘要：
透明细胞棘皮瘤（CCA）和鳞状细胞癌（SCC）代表皮肤肿瘤学中的不同实体，每一个都带来了独特的诊断和治疗挑战。CCA是一种罕见的，良性表皮生长，通常与人乳头瘤病毒（HPV）感染无关，而SCC,一种更具侵袭性的皮肤癌，与紫外线（UV）暴露和HPV有关。了解这些情况在单个患者中的共同发生可以提高诊断准确性和治疗结果。我们报告了一名64岁的男性，他接受了右腹股沟疣状病变的手术，与角化SCC一起被诊断为HPV阳性CCA。2024年1月的文献搜索显示，将HPV与CCA直接联系起来的证据有限，表明需要进一步调查。HPV和CCA之间的推测性关联值得更深入的探索，特别是考虑到HPV可能通过间接机制促进病变发展。老年患者中CCA和SCC的共存呈现出独特的临床情景。这强调了需要警惕的诊断和量身定制的治疗策略，突出了在理解CCA发病机制方面的差距，特别是它与HPV的潜在关联。进一步的研究对于阐明控制这些条件的复杂相互作用和制定有针对性的干预措施至关重要。
