小鼠中 Tmem268 的缺失通过下调 CD11b 信号传导来抑制抗感染免疫应答。
关键词: CD11b Integrin Phagocytes Sepsis TMEM268
Mesh : Animals Humans Mice CD11b Antigen / metabolism genetics Cell Adhesion / genetics Cell Movement / genetics Down-Regulation Endosomes / metabolism Gene Deletion Lysosomes / metabolism Membrane Proteins / genetics metabolism Mice, Inbred C57BL Mice, Knockout Phagocytes / metabolism immunology Phagocytosis Sepsis / genetics immunology metabolism Signal Transduction
来 源:
DOI:10.1038/s44319-024-00141-6
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