关键词: Chronic kidney disease dysgeusia malnutrition prevention treatment

来  源:   DOI:10.1053/j.jrn.2024.04.005

Abstract:
Dysgeusia is a common altered taste perception in chronic kidney disease patients. The study aims to identify available treatments for educating, screening, and clinically managing dysgeusia in this population. A scoping review was conducted following the protocol of Arksey and O\'Malley, incorporating the Joanna Briggs Institute methodology, and adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Among the 424 identified records, 13 studies were included. Screening methodologies, educational strategies, particularly a hospital-based program focusing on salt reduction, showed a significant improvement in dysgeusia (P < .001). The identified clinical treatments exclusively included oral zinc supplementation, with dosages ranging from 50 to 220 mg, reporting heterogeneous results not consistent across different studies. The personalized management of dysgeusia associated with chronic kidney disease is crucial, requiring targeted education and treatment protocols to prevent and address nutritional complications such as malnutrition.
摘要:
目标:味觉障碍,CKD患者常见的味觉改变,导致味觉敏锐度降低,受损的盐检测,和金属味觉,导致营养改变。该研究旨在确定可用于教育的治疗方法,筛选,和临床管理该人群的味觉障碍。
方法:根据Arksey和O\'Malley的协议进行了范围审查,结合JBI方法,并遵守PRISMA-ScR准则。审查协议已在开放科学框架(https://doi.org/10.17605/OSF)上注册。IO/RS2A6)。
结果:在424条确定的记录中,共纳入13项研究。筛选方法包括味觉敏锐度测试,评估量表,与棉签涂抹器和冲洗溶液集成的化学测试。此外,教育策略,特别是以医院为基础的减少盐的计划,显着改善了味觉障碍(p<0.001)。确定的临床治疗仅包括口服锌补充剂,剂量范围从50到220毫克,报告的异质性结果在不同研究中不一致。
结论:与CKD相关的味觉障碍的个性化管理至关重要,需要有针对性的教育和治疗方案,以预防和解决营养并发症,如营养不良。结果的异质性强调需要进一步的高质量研究以产生可靠的科学证据。
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