Abstract：
OBJECTIVE: Tegmen and superior semicircular canal defects have been well studied, yet the factors contributing to their onset and progression are widely debated. The clinical utility of intraoperative intracranial pressure measurements has yet to be tested. This report aims to use intraoperative opening pressure and concurrent superior semicircular canal dehiscence (SSCD) to analyze factors influencing disease course and clinical outcomes in patients with tegmen dehiscence.
METHODS: A retrospective analysis of 61 patients who underwent tegmen defect repair was performed. Multiple variables of interest including body mass index (BMI), presence of SSCD, presence of dural venous sinus stenosis, opening pressure, and acetazolamide therapy use were recorded. The cohort was divided into those with or without concurrent SSCD and those presenting with or without cerebrospinal fluid (CSF) leak for analysis.
RESULTS: A linear relationship between opening pressure and BMI (p = 0.009) was noted; however, intraoperative opening pressure was not associated with disease outcome. Concurrent SSCD was present in 25 % of patients, while 62 % presented with CSF leak. The concurrent SSCD group exhibited higher opening pressure, higher likelihood of having dural sinus stenosis, and higher likelihood of being discharged on acetazolamide. The CSF leak group had higher likelihood of obstructive sleep apnea and persistent symptoms.
CONCLUSIONS: In patients undergoing tegmen defect repair, concurrent SSCD suggests increased disease severity. The presence of preoperative CSF leak predicts persistent symptoms following repair. BMI is linearly correlated with intracranial pressure in these patients.
METHODS: A retrospective analysis of 61 patients who underwent tegmen defect repair was performed. Multiple variables of interest including body mass index (BMI), presence of SSCD, presence of dural venous sinus stenosis, opening pressure, and acetazolamide therapy use were recorded. The cohort was divided into those with or without concurrent SSCD and those presenting with or without cerebrospinal fluid (CSF) leak for analysis.
RESULTS: A linear relationship between opening pressure and BMI (p = 0.009) was noted; however, intraoperative opening pressure was not associated with disease outcome. Concurrent SSCD was present in 25 % of patients, while 62 % presented with CSF leak. The concurrent SSCD group exhibited higher opening pressure, higher likelihood of having dural sinus stenosis, and higher likelihood of being discharged on acetazolamide. The CSF leak group had higher likelihood of obstructive sleep apnea and persistent symptoms.
CONCLUSIONS: In patients undergoing tegmen defect repair, concurrent SSCD suggests increased disease severity. The presence of preoperative CSF leak predicts persistent symptoms following repair. BMI is linearly correlated with intracranial pressure in these patients.
摘要：
目的：Tegmen和上半规管缺损已得到很好的研究，然而，导致其发病和进展的因素仍存在广泛争议。术中颅内压测量的临床实用性尚待测试。本报告旨在使用术中开放压力和并发上半规管裂开（SSCD）来分析影响受精门裂开患者病程和临床结局的因素。
方法：回顾性分析61例接受包膜缺损修复的患者。多个感兴趣的变量，包括体重指数（BMI），SSCD的存在，硬脑膜静脉窦狭窄的存在，开启压力,并记录乙酰唑胺治疗的使用情况.该队列分为有或没有并发SSCD的患者和有或没有脑脊液（CSF）泄漏的患者进行分析。
结果：注意到打开压力与BMI之间的线性关系（p=0.009）；但是，术中开启压力与疾病预后无关.并发SSCD出现在25%的患者中，而62%的人出现脑脊液渗漏。并发SSCD组表现出更高的开启压力，硬膜窦狭窄的可能性更高，和更高的可能性被释放的乙酰唑胺。CSF泄漏组出现阻塞性睡眠呼吸暂停和持续症状的可能性更高。
结论：在接受tegmen缺损修复的患者中，并发SSCD提示疾病严重程度增加.术前脑脊液漏的存在预示着修复后的持续症状。这些患者的BMI与颅内压呈线性关系。
方法：回顾性分析61例接受包膜缺损修复的患者。多个感兴趣的变量，包括体重指数（BMI），SSCD的存在，硬脑膜静脉窦狭窄的存在，开启压力,并记录乙酰唑胺治疗的使用情况.该队列分为有或没有并发SSCD的患者和有或没有脑脊液（CSF）泄漏的患者进行分析。
结果：注意到打开压力与BMI之间的线性关系（p=0.009）；但是，术中开启压力与疾病预后无关.并发SSCD出现在25%的患者中，而62%的人出现脑脊液渗漏。并发SSCD组表现出更高的开启压力，硬膜窦狭窄的可能性更高，和更高的可能性被释放的乙酰唑胺。CSF泄漏组出现阻塞性睡眠呼吸暂停和持续症状的可能性更高。
结论：在接受tegmen缺损修复的患者中，并发SSCD提示疾病严重程度增加.术前脑脊液漏的存在预示着修复后的持续症状。这些患者的BMI与颅内压呈线性关系。
