PDF(Pubmed)
Abstract：
Retinopathy of prematurity (ROP) is a major treatable cause of childhood blindness. Thus, epidemiological investigations are necessary for detecting and preventing ROP. Determining risk factors for ROP are also essential to improve screening methods. Therefore, we aimed to investigate the incidence and risk factors of ROP in Korea. The National Health Insurance Service (NHIS) covers almost all Koreans. Furthermore, the National Health Screening Program for Infants and Children (NHSPIC) is a government-run, health-screening program for children aged < 6 years. We used the NHIS-Infants and Children\'s Health Screening cohort database to evaluate the incidence of preterm infants and ROP. The database contains data on 84,005 participants, drawn from 5% of the NHSPIC survey on participants born annually during 2008 to 2012. Sociodemographic factors and systemic diseases were assessed as potential risk factors for ROP. We identified 2615 premature infants (3.11%); 846 of them had ROP (cumulative incidence: 32.4%). Although preterm births increased annually in 2008 to 2012, the ROP incidence in preterm infants did not increase by the birth year. Twenty patients (2.4%) with ROP underwent laser photocoagulation or surgery. Extremely low birth weight was a high risk factor (odds ratio [OR] = 49.86, P < .001). Moreover, chorioamnionitis (OR = 2.77, P = .028), respiratory distress syndrome (OR = 4.09, P < .001), apnea (OR = 1.59, P = .008), anemia (OR = 2.41, P < .001), and intraventricular hemorrhage (OR = 2.34, P < .001) were found to be risk factors for ROP. In conclusion, the incidence of premature babies increased between 2008 and 2012. However, the overall incidence of ROP among premature infants remained unchanged by birth year. Our findings revealed the roles of birth weight, respiratory conditions, anemia, and intraventricular hemorrhage in ROP.
摘要：
早产儿视网膜病变（ROP）是儿童失明的主要可治疗原因。因此，流行病学调查对于检测和预防ROP是必要的。确定ROP的危险因素对于改进筛查方法也至关重要。因此,我们旨在调查韩国ROP的发病率和危险因素.国家健康保险服务（NHIS）覆盖几乎所有韩国人。此外，国家婴儿和儿童健康筛查计划（NHSPIC）是政府管理的，6岁以下儿童的健康筛查计划。我们使用NHIS-婴儿和儿童健康筛查队列数据库来评估早产儿和ROP的发生率。该数据库包含84,005名参与者的数据，来自NHSPIC对2008年至2012年期间每年出生的参与者的5%调查。社会人口统计学因素和全身性疾病被评估为ROP的潜在危险因素。我们确定了2615名早产儿（3.11％）；其中846名患有ROP（累积发生率：32.4％）。尽管早产在2008年至2012年呈逐年上升趋势，但早产儿的ROP发病率在出生年份并没有增加。20例ROP患者（2.4％）接受了激光光凝或手术。极低出生体重是高危因素(比值比[OR]=49.86,P<.001)。此外，绒毛膜羊膜炎（OR=2.77，P=0.028），呼吸窘迫综合征(OR=4.09,P<.001),呼吸暂停（OR=1.59，P=0.008），贫血（OR=2.41，P<.001），脑室出血（OR=2.34，P<.001）是ROP的危险因素。总之,早产儿的发病率在2008年至2012年间增加.然而,早产儿ROP的总体发病率在出生年份保持不变.我们的发现揭示了出生体重的作用，呼吸状况,贫血,ROP中的脑室内出血。
