PDF(Pubmed)
Abstract：
BACKGROUND: Deep brain stimulation (DBS) reliably ameliorates cardinal motor symptoms in Parkinson\'s disease (PD) and essential tremor (ET). However, the effects of DBS on speech, voice and language have been inconsistent and have not been examined comprehensively in a single study.
OBJECTIVE: We conducted a systematic analysis of literature by reviewing studies that examined the effects of DBS on speech, voice and language in PD and ET.
METHODS: A total of 675 publications were retrieved from PubMed, Embase, CINHAL, Web of Science, Cochrane Library and Scopus databases. Based on our selection criteria, 90 papers were included in our analysis. The selected publications were categorized into four subcategories: Fluency, Word production, Articulation and phonology and Voice quality.
RESULTS: The results suggested a long-term decline in verbal fluency, with more studies reporting deficits in phonemic fluency than semantic fluency following DBS. Additionally, high frequency stimulation, left-sided and bilateral DBS were associated with worse verbal fluency outcomes. Naming improved in the short-term following DBS-ON compared to DBS-OFF, with no long-term differences between the two conditions. Bilateral and low-frequency DBS demonstrated a relative improvement for phonation and articulation. Nonetheless, long-term DBS exacerbated phonation and articulation deficits. The effect of DBS on voice was highly variable, with both improvements and deterioration in different measures of voice.
CONCLUSIONS: This was the first study that aimed to combine the outcome of speech, voice, and language following DBS in a single systematic review. The findings revealed a heterogeneous pattern of results for speech, voice, and language across DBS studies, and provided directions for future studies.
OBJECTIVE: We conducted a systematic analysis of literature by reviewing studies that examined the effects of DBS on speech, voice and language in PD and ET.
METHODS: A total of 675 publications were retrieved from PubMed, Embase, CINHAL, Web of Science, Cochrane Library and Scopus databases. Based on our selection criteria, 90 papers were included in our analysis. The selected publications were categorized into four subcategories: Fluency, Word production, Articulation and phonology and Voice quality.
RESULTS: The results suggested a long-term decline in verbal fluency, with more studies reporting deficits in phonemic fluency than semantic fluency following DBS. Additionally, high frequency stimulation, left-sided and bilateral DBS were associated with worse verbal fluency outcomes. Naming improved in the short-term following DBS-ON compared to DBS-OFF, with no long-term differences between the two conditions. Bilateral and low-frequency DBS demonstrated a relative improvement for phonation and articulation. Nonetheless, long-term DBS exacerbated phonation and articulation deficits. The effect of DBS on voice was highly variable, with both improvements and deterioration in different measures of voice.
CONCLUSIONS: This was the first study that aimed to combine the outcome of speech, voice, and language following DBS in a single systematic review. The findings revealed a heterogeneous pattern of results for speech, voice, and language across DBS studies, and provided directions for future studies.
摘要：
背景：脑深部电刺激（DBS）能可靠地改善帕金森病（PD）和特发性震颤（ET）的主要运动症状。然而,DBS对言语的影响，语音和语言不一致，没有在一项研究中进行全面检查。
目的：我们通过回顾研究DBS对言语的影响，对文献进行了系统分析，PD和ET中的语音和语言。
方法：共从PubMed检索到675种出版物，Embase,CINHAL,WebofScience,Cochrane图书馆和Scopus数据库。根据我们的选择标准，90篇论文被纳入我们的分析。选定的出版物分为四个子类别：流利度，Word制作,清晰度和语音和语音质量。
结果：结果表明，语言流畅性长期下降，有更多的研究报告语音流畅性比DBS后的语义流畅性不足。此外,高频刺激,左侧和双侧DBS与较差的言语流畅性结果相关.与DBS-OFF相比，DBS-ON后的短期命名有所改善，这两个条件之间没有长期差异。双边和低频DBS在发声和发音方面表现出相对改善。尽管如此，长期DBS加剧了发音和发音缺陷。DBS对语音的影响是高度可变的，声音的不同衡量标准都有改善和恶化。
结论：这是第一项旨在结合言语结果的研究，声音,和语言遵循星展银行在一个单一的系统审查。这些发现揭示了语音结果的异质性，声音,以及DBS研究中的语言，为今后的研究提供了方向。
目的：我们通过回顾研究DBS对言语的影响，对文献进行了系统分析，PD和ET中的语音和语言。
方法：共从PubMed检索到675种出版物，Embase,CINHAL,WebofScience,Cochrane图书馆和Scopus数据库。根据我们的选择标准，90篇论文被纳入我们的分析。选定的出版物分为四个子类别：流利度，Word制作,清晰度和语音和语音质量。
结果：结果表明，语言流畅性长期下降，有更多的研究报告语音流畅性比DBS后的语义流畅性不足。此外,高频刺激,左侧和双侧DBS与较差的言语流畅性结果相关.与DBS-OFF相比，DBS-ON后的短期命名有所改善，这两个条件之间没有长期差异。双边和低频DBS在发声和发音方面表现出相对改善。尽管如此，长期DBS加剧了发音和发音缺陷。DBS对语音的影响是高度可变的，声音的不同衡量标准都有改善和恶化。
结论：这是第一项旨在结合言语结果的研究，声音,和语言遵循星展银行在一个单一的系统审查。这些发现揭示了语音结果的异质性，声音,以及DBS研究中的语言，为今后的研究提供了方向。
