PDF(Pubmed)
Abstract：
Cardiac arrest survivors suffer the repercussions of anoxic brain injury, a critical factor influencing long-term prognosis. This injury is characterised by profound and enduring metabolic impairment. Ketone bodies, an alternative energetic resource in physiological states such as exercise, fasting, and extended starvation, are avidly taken up and used by the brain. Both the ketogenic diet and exogenous ketone supplementation have been associated with neuroprotective effects across a spectrum of conditions. These include refractory epilepsy, neurodegenerative disorders, cognitive impairment, focal cerebral ischemia, and traumatic brain injuries. Beyond this, ketone bodies possess a plethora of attributes that appear to be particularly favourable after cardiac arrest. These encompass anti-inflammatory effects, the attenuation of oxidative stress, the improvement of mitochondrial function, a glucose-sparing effect, and the enhancement of cardiac function. The aim of this manuscript is to appraise pertinent scientific literature on the topic through a narrative review. We aim to encapsulate the existing evidence and underscore the potential therapeutic value of ketone bodies in the context of cardiac arrest to provide a rationale for their use in forthcoming translational research efforts.
摘要：
心脏骤停幸存者遭受缺氧脑损伤的影响，影响长期预后的关键因素。这种损伤的特征是严重和持久的代谢损害。酮的尸体,在生理状态下的替代能量资源，如运动，禁食,和长期的饥饿，被大脑狂热地吸收和利用。生酮饮食和外源性酮补充都与一系列疾病的神经保护作用有关。这些包括难治性癫痫，神经退行性疾病，认知障碍，局灶性脑缺血,和创伤性脑损伤。除此之外,酮体具有许多在心脏骤停后似乎特别有利的属性。这些包括抗炎作用，氧化应激的衰减，线粒体功能的改善，节省葡萄糖的效果，和心脏功能的增强。本手稿的目的是通过叙事审查来评估有关该主题的相关科学文献。我们旨在囊括现有证据，并强调酮体在心脏骤停情况下的潜在治疗价值，为其在即将进行的转化研究工作中的使用提供理论依据。
